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1w6y

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==CRYSTAL STRUCTURE OF A MUTANT W92A IN KETOSTEROID ISOMERASE (KSI) FROM PSEUDOMONAS PUTIDA BIOTYPE B==
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<StructureSection load='1w6y' size='340' side='right' caption='[[1w6y]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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==crystal structure of a mutant W92A in ketosteroid isomerase (KSI) from Pseudomonas putida biotype B==
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<StructureSection load='1w6y' size='340' side='right'caption='[[1w6y]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1w6y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W6Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W6Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1w6y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W6Y FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EQU:EQUILENIN'>EQU</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1c7h|1c7h]], [[1cqs|1cqs]], [[1dmm|1dmm]], [[1dmn|1dmn]], [[1dmq|1dmq]], [[1e3r|1e3r]], [[1e3v|1e3v]], [[1e97|1e97]], [[1ea2|1ea2]], [[1gs3|1gs3]], [[1k41|1k41]], [[1ogx|1ogx]], [[1oh0|1oh0]], [[1oho|1oho]], [[1opy|1opy]], [[1vzz|1vzz]], [[1w00|1w00]], [[1w01|1w01]], [[1w02|1w02]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EQU:EQUILENIN'>EQU</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Steroid_Delta-isomerase Steroid Delta-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.3.1 5.3.3.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w6y OCA], [https://pdbe.org/1w6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w6y RCSB], [https://www.ebi.ac.uk/pdbsum/1w6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w6y ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w6y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w6y RCSB], [http://www.ebi.ac.uk/pdbsum/1w6y PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/SDIS_PSEPU SDIS_PSEPU]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/1w6y_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/1w6y_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w6y ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1w6y" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Pseudomonas putida]]
[[Category: Pseudomonas putida]]
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[[Category: Steroid Delta-isomerase]]
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[[Category: Choi KY]]
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[[Category: Choi, K Y.]]
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[[Category: Kim Y-G]]
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[[Category: Kim, Y G.]]
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[[Category: Nam GH]]
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[[Category: Nam, G H.]]
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[[Category: Oh B-H]]
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[[Category: Oh, B H.]]
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[[Category: Yun YS]]
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[[Category: Yun, Y S.]]
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[[Category: Closed barrel]]
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[[Category: Coneshell]]
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[[Category: Conformational stability]]
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[[Category: Curved b-sheet]]
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[[Category: Hydrophobic cluster]]
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[[Category: Isomerase]]
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[[Category: Ketosteroid isomerase]]
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[[Category: Solvent-exposed]]
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Current revision

crystal structure of a mutant W92A in ketosteroid isomerase (KSI) from Pseudomonas putida biotype B

PDB ID 1w6y

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