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1y3a

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==Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange==
==Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange==
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<StructureSection load='1y3a' size='340' side='right' caption='[[1y3a]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='1y3a' size='340' side='right'caption='[[1y3a]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1y3a]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y3A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1y3a]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y3A FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GNAI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y3a RCSB], [http://www.ebi.ac.uk/pdbsum/1y3a PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3a OCA], [https://pdbe.org/1y3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y3a RCSB], [https://www.ebi.ac.uk/pdbsum/1y3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y3a ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y3/1y3a_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y3/1y3a_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y3a ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1y3a" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Guanine nucleotide-binding protein|Guanine nucleotide-binding protein]]
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blaesius, R.]]
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[[Category: Large Structures]]
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[[Category: Bodor, E T.]]
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[[Category: Blaesius R]]
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[[Category: Fredericks, Z.]]
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[[Category: Bodor ET]]
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[[Category: Harden, T K.]]
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[[Category: Fredericks Z]]
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[[Category: Jezyk, M R.]]
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[[Category: Harden TK]]
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[[Category: Johnston, C A.]]
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[[Category: Jezyk MR]]
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[[Category: Jones, M B.]]
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[[Category: Johnston CA]]
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[[Category: Ramer, J K.]]
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[[Category: Jones MB]]
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[[Category: Siderovski, D P.]]
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[[Category: Ramer JK]]
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[[Category: Sondek, J.]]
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[[Category: Siderovski DP]]
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[[Category: Watts, V J.]]
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[[Category: Sondek J]]
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[[Category: Willard, F S.]]
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[[Category: Watts VJ]]
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[[Category: Protein-peptide complex]]
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[[Category: Willard FS]]
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[[Category: Signaling protein]]
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Current revision

Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange

PDB ID 1y3a

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