1z23

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==The serine-rich domain from Crk-associated substrate (p130Cas)==
==The serine-rich domain from Crk-associated substrate (p130Cas)==
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<StructureSection load='1z23' size='340' side='right' caption='[[1z23]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1z23' size='340' side='right'caption='[[1z23]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1z23]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z23 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1z23]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z23 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z23 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z23 RCSB], [http://www.ebi.ac.uk/pdbsum/1z23 PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z23 OCA], [https://pdbe.org/1z23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z23 RCSB], [https://www.ebi.ac.uk/pdbsum/1z23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z23 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BCAR1_RAT BCAR1_RAT] Appears to have a central function in transformation of some cell types.
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== Function ==
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[https://www.uniprot.org/uniprot/BCAR1_RAT BCAR1_RAT] Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z2/1z23_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z2/1z23_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z23 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1z23" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Briknarova, K.]]
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[[Category: Briknarova K]]
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[[Category: Eggleston, E.]]
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[[Category: Eggleston E]]
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[[Category: Ely, K R.]]
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[[Category: Ely KR]]
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[[Category: Havert, M L.]]
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[[Category: Havert ML]]
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[[Category: Hoyt, D W.]]
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[[Category: Hoyt DW]]
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[[Category: Li, C.]]
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[[Category: Li C]]
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[[Category: Nasertorabi, F.]]
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[[Category: Nasertorabi F]]
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[[Category: Olson, A J.]]
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[[Category: Olson AJ]]
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[[Category: Vuori, K.]]
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[[Category: Vuori K]]
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[[Category: Cell adhesion]]
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[[Category: Four-helix bundle]]
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Current revision

The serine-rich domain from Crk-associated substrate (p130Cas)

PDB ID 1z23

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