1ugv
From Proteopedia
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==Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)== | ==Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)== | ||
| - | <StructureSection load='1ugv' size='340' side='right' caption='[[1ugv | + | <StructureSection load='1ugv' size='340' side='right'caption='[[1ugv]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1ugv]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1ugv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UGV FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ugv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugv OCA], [https://pdbe.org/1ugv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ugv RCSB], [https://www.ebi.ac.uk/pdbsum/1ugv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ugv ProSAT], [https://www.topsan.org/Proteins/RSGI/1ugv TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN] Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[https://omim.org/entry/607785 607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN] GTPase-activating protein for RHOA and CDC42. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ug/1ugv_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ug/1ugv_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ugv ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Aoki | + | [[Category: Large Structures]] |
| - | [[Category: Hayashi | + | [[Category: Aoki M]] |
| - | [[Category: Hirota | + | [[Category: Hayashi F]] |
| - | [[Category: Inoue | + | [[Category: Hirota H]] |
| - | [[Category: Inoue | + | [[Category: Inoue K]] |
| - | [[Category: Kigawa | + | [[Category: Inoue M]] |
| - | [[Category: Kikuno | + | [[Category: Kigawa T]] |
| - | [[Category: Matsuda | + | [[Category: Kikuno R]] |
| - | [[Category: Matsuo | + | [[Category: Matsuda T]] |
| - | [[Category: Nagase | + | [[Category: Matsuo Y]] |
| - | [[Category: Nakayama | + | [[Category: Nagase T]] |
| - | [[Category: Ohara | + | [[Category: Nakayama M]] |
| - | [[Category: Osanai | + | [[Category: Ohara O]] |
| - | + | [[Category: Osanai T]] | |
| - | [[Category: Seki | + | [[Category: Seki E]] |
| - | [[Category: Shirouzu | + | [[Category: Shirouzu M]] |
| - | [[Category: Tanaka | + | [[Category: Tanaka A]] |
| - | [[Category: Terada | + | [[Category: Terada T]] |
| - | [[Category: Yabuki | + | [[Category: Yabuki T]] |
| - | [[Category: Yokoyama | + | [[Category: Yokoyama S]] |
| - | [[Category: Yoshida | + | [[Category: Yoshida M]] |
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Current revision
Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)
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Categories: Homo sapiens | Large Structures | Aoki M | Hayashi F | Hirota H | Inoue K | Inoue M | Kigawa T | Kikuno R | Matsuda T | Matsuo Y | Nagase T | Nakayama M | Ohara O | Osanai T | Seki E | Shirouzu M | Tanaka A | Terada T | Yabuki T | Yokoyama S | Yoshida M
