1hje

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[[Image:1hje.gif|left|200px]]
 
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{{Structure
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==Crystal structure of alpha-conotoxin SI==
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|PDB= 1hje |SIZE=350|CAPTION= <scene name='initialview01'>1hje</scene>, resolution 0.75&Aring;
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<StructureSection load='1hje' size='340' side='right'caption='[[1hje]], [[Resolution|resolution]] 0.75&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene>
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<table><tr><td colspan='2'>[[1hje]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HJE FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.75&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hje OCA], [https://pdbe.org/1hje PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hje RCSB], [https://www.ebi.ac.uk/pdbsum/1hje PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hje ProSAT]</span></td></tr>
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</table>
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'''CRYSTAL STRUCTURE OF ALPHA-CONOTOXIN SI'''
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== Function ==
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[https://www.uniprot.org/uniprot/CA1_CONST CA1_CONST] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (PubMed:3196703). Is active on muscle nAChR (IC(50)=113 nM on adult subtype (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) and IC(50)=142 nM on fetal subtype (alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE)) (PubMed:35357806, PubMed:9174364). On mice muscle receptors, its higher affinity site is the alpha/delta nAChR subunit interface (PubMed:9174364). On Torpedo receptors, it does not distinguish between alpha/delta and alpha/gamma acetylcholine-binding sites (PubMed:9174364). In vivo, causes paralysis followed by death when injected into goldfish (PubMed:3196703). In contrast, has no effect on mice, when similar doses are intraperitoneally or intracerebrally injected (PubMed:3196703).<ref>PMID:3196703</ref> <ref>PMID:35357806</ref> <ref>PMID:9174364</ref>
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== References ==
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==About this Structure==
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<references/>
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1HJE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJE OCA].
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Barany, G.]]
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[[Category: Conus striatus]]
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[[Category: Hargittai, B.]]
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[[Category: Large Structures]]
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[[Category: Janes, R W.]]
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[[Category: Barany G]]
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[[Category: Maclean, E J.]]
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[[Category: Hargittai B]]
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[[Category: Teat, S J.]]
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[[Category: Janes RW]]
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[[Category: NH2]]
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[[Category: Maclean EJ]]
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[[Category: conotoxin]]
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[[Category: Teat SJ]]
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[[Category: nicotinic acetylcholine receptor]]
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[[Category: toxin]]
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[[Category: venom]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:37:48 2008''
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Current revision

Crystal structure of alpha-conotoxin SI

PDB ID 1hje

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