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1hjd

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[[Image:1hjd.jpg|left|200px]]
 
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{{Structure
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==Melanoma inhibitory activity (MIA) protein==
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|PDB= 1hjd |SIZE=350|CAPTION= <scene name='initialview01'>1hjd</scene>
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<StructureSection load='1hjd' size='340' side='right'caption='[[1hjd]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1hjd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HJD FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hjd OCA], [https://pdbe.org/1hjd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hjd RCSB], [https://www.ebi.ac.uk/pdbsum/1hjd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hjd ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''MELANOMA INHIBITORY ACTIVITY (MIA) PROTEIN'''
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[https://www.uniprot.org/uniprot/MIA_HUMAN MIA_HUMAN] Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Melanoma inhibitory activity (MIA) protein is a clinically valuable marker in patients with malignant melanoma, as enhanced values diagnose metastatic melanoma stages III and IV. Here we show that the recombinant human MIA adopts an SH3 domain-like fold in solution, with two perpendicular, antiparallel, three- and five-stranded beta-sheets. In contrast to known structures with the SH3 domain fold, MIA is a single-domain protein, and contains an additional antiparallel beta-sheet and two disulfide bonds. MIA is also the first extracellular protein found to have the SH3 domain-like fold. Furthermore, we show that MIA interacts with fibronectin and that the peptide ligands identified for MIA exhibit a matching sequence to type III human fibronectin repeats, especially to FN14, which is close to an integrin alpha4beta1 binding site. The present study, therefore, may explain the role of MIA in metastasis in vivo, and supports a model in which the binding of human MIA to type III repeats of fibronectin competes with integrin binding, thus detaching cells from the extracellular matrix.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hj/1hjd_consurf.spt"</scriptWhenChecked>
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==Disease==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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Known disease associated with this structure: Myocardial infarction, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611082 611082]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hjd ConSurf].
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1HJD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJD OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain-like fold., Stoll R, Renner C, Zweckstetter M, Bruggert M, Ambrosius D, Palme S, Engh RA, Golob M, Breibach I, Buettner R, Voelter W, Holak TA, Bosserhoff AK, EMBO J. 2001 Feb 1;20(3):340-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11157741 11157741]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bosserhoff, A K.]]
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[[Category: Bosserhoff AK]]
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[[Category: Holak, T A.]]
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[[Category: Holak TA]]
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[[Category: Stoll, R.]]
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[[Category: Stoll R]]
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[[Category: Voelter, W.]]
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[[Category: Voelter W]]
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[[Category: growth factor]]
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[[Category: signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:37:50 2008''
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Current revision

Melanoma inhibitory activity (MIA) protein

PDB ID 1hjd

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