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2c06

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==NMR-BASED MODEL OF THE COMPLEX OF THE TOXIN KID AND A 5-NUCLEOTIDE SUBSTRATE RNA FRAGMENT (AUACA)==
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<StructureSection load='2c06' size='340' side='right' caption='[[2c06]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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==NMR-based model of the complex of the toxin Kid and a 5-nucleotide substrate RNA fragment (AUACA)==
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<StructureSection load='2c06' size='340' side='right'caption='[[2c06]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2c06]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C06 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C06 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2c06]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C06 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1m1f|1m1f]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c06 OCA], [https://pdbe.org/2c06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c06 RCSB], [https://www.ebi.ac.uk/pdbsum/2c06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c06 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c06 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c06 RCSB], [http://www.ebi.ac.uk/pdbsum/2c06 PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/PEMK_ECOLX PEMK_ECOLX] Toxic component of a type II toxin-antitoxin (TA) module. Probably functions as an endoribonuclease. Responsible for the stable maintenance of the plasmid during cell division by postsegregational killing of plasmid-less daughter cells. Neutralized by coexpression with cognate antitoxin PemI. Both PemI and PemK proteins bind to the promoter region of the pem operon to autoregulate their synthesis.<ref>PMID:2832364</ref> <ref>PMID:8455570</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c06_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c06_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c06 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2c06" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Boelens, R.]]
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[[Category: Large Structures]]
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[[Category: Bonvin, A M.J J.]]
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[[Category: Boelens R]]
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[[Category: Diaz-Orejas, R.]]
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[[Category: Bonvin AMJJ]]
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[[Category: Heuvel, R H.H Van Den.]]
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[[Category: Diaz-Orejas R]]
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[[Category: Kamphuis, M B.]]
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[[Category: Kamphuis MB]]
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[[Category: Lemonnier, M.]]
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[[Category: Lemonnier M]]
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[[Category: Monti, M C.]]
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[[Category: Monti MC]]
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[[Category: Munoz-Gomez, A.]]
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[[Category: Munoz-Gomez A]]
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[[Category: Dna replication]]
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[[Category: Van Den Heuvel RHH]]
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[[Category: Docking]]
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[[Category: Mazf]]
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[[Category: Plasmid maintenance]]
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[[Category: Post segregational killing]]
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[[Category: Protein-rna complex]]
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[[Category: Ribonuclease]]
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[[Category: Rna cleavage]]
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[[Category: Rnase]]
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[[Category: Toxin]]
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[[Category: Toxin-antitoxin]]
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Current revision

NMR-based model of the complex of the toxin Kid and a 5-nucleotide substrate RNA fragment (AUACA)

PDB ID 2c06

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