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2c1b
From Proteopedia
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<StructureSection load='2c1b' size='340' side='right' caption='[[2c1b]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='2c1b' size='340' side='right' caption='[[2c1b]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2c1b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2c1b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C1B FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CQP:(4R,2S)-5-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE'>CQP</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CQP:(4R,2S)-5-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE'>CQP</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kmu|1kmu]], [[1kmw|1kmw]], [[1q24|1q24]], [[1q61|1q61]], [[1q62|1q62]], [[1q8t|1q8t]], [[1q8u|1q8u]], [[1q8w|1q8w]], [[1smh|1smh]], [[1stc|1stc]], [[1sve|1sve]], [[1svg|1svg]], [[1svh|1svh]], [[1szm|1szm]], [[1veb|1veb]], [[1ydr|1ydr]], [[1yds|1yds]], [[1ydt|1ydt]], [[2c1a|2c1a]], [[1cmk|1cmk]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kmu|1kmu]], [[1kmw|1kmw]], [[1q24|1q24]], [[1q61|1q61]], [[1q62|1q62]], [[1q8t|1q8t]], [[1q8u|1q8u]], [[1q8w|1q8w]], [[1smh|1smh]], [[1stc|1stc]], [[1sve|1sve]], [[1svg|1svg]], [[1svh|1svh]], [[1szm|1szm]], [[1veb|1veb]], [[1ydr|1ydr]], [[1yds|1yds]], [[1ydt|1ydt]], [[2c1a|2c1a]], [[1cmk|1cmk]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c1b RCSB], [http://www.ebi.ac.uk/pdbsum/2c1b PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1b OCA], [http://pdbe.org/2c1b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c1b RCSB], [http://www.ebi.ac.uk/pdbsum/2c1b PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IPKA_HUMAN IPKA_HUMAN]] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c1b ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2c1b" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Bovin]] |
| - | [[Category: | + | [[Category: Transferase]] |
| - | [[Category: Aherne, G W | + | [[Category: Aherne, G W]] |
| - | [[Category: Bavetsias, V | + | [[Category: Bavetsias, V]] |
| - | [[Category: Berdini, V | + | [[Category: Berdini, V]] |
| - | [[Category: Caldwell, J | + | [[Category: Caldwell, J]] |
| - | [[Category: Collins, I | + | [[Category: Collins, I]] |
| - | [[Category: Davies, T G | + | [[Category: Davies, T G]] |
| - | [[Category: Donald, A | + | [[Category: Donald, A]] |
| - | [[Category: Fonseca, T | + | [[Category: Fonseca, T]] |
| - | [[Category: Garrett, M D | + | [[Category: Garrett, M D]] |
| - | [[Category: Hunter, L J | + | [[Category: Hunter, L J]] |
| - | [[Category: Mcdonald, E | + | [[Category: Mcdonald, E]] |
| - | [[Category: Rowlands, M G | + | [[Category: Rowlands, M G]] |
| - | [[Category: Seavers, L C.A | + | [[Category: Seavers, L C.A]] |
| - | [[Category: Woodhead, S J | + | [[Category: Woodhead, S J]] |
| - | [[Category: Workman, P | + | [[Category: Workman, P]] |
| - | [[Category: Wyatt, P G | + | [[Category: Wyatt, P G]] |
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Camp]] | [[Category: Camp]] | ||
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[[Category: Protein kinase inhibitor]] | [[Category: Protein kinase inhibitor]] | ||
[[Category: Serine/threonine-protein kinase]] | [[Category: Serine/threonine-protein kinase]] | ||
| - | [[Category: Transferase]] | ||
[[Category: Transferase-inhibitor complex]] | [[Category: Transferase-inhibitor complex]] | ||
[[Category: Transferase/inhibitor]] | [[Category: Transferase/inhibitor]] | ||
Current revision
STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE
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Categories: Bovin | Transferase | Aherne, G W | Bavetsias, V | Berdini, V | Caldwell, J | Collins, I | Davies, T G | Donald, A | Fonseca, T | Garrett, M D | Hunter, L J | Mcdonald, E | Rowlands, M G | Seavers, L C.A | Woodhead, S J | Workman, P | Wyatt, P G | Atp-binding | Camp | Phosphorylation | Protein kinase inhibitor | Serine/threonine-protein kinase | Transferase-inhibitor complex | Transferase/inhibitor
