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2b2e

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==RNA stemloop from bacteriophage MS2 complexed with an N87S,E89K mutant MS2 capsid==
==RNA stemloop from bacteriophage MS2 complexed with an N87S,E89K mutant MS2 capsid==
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<StructureSection load='2b2e' size='340' side='right' caption='[[2b2e]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
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<StructureSection load='2b2e' size='340' side='right'caption='[[2b2e]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2b2e]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacterio_phage_ms2 Enterobacterio phage ms2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B2E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2b2e]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_MS2 Escherichia phage MS2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B2E FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bny|2bny]], [[1aq3|1aq3]], [[1aq4|1aq4]], [[1bms|1bms]], [[1dzs|1dzs]], [[1e6t|1e6t]], [[2b2d|2b2d]], [[2b2g|2b2g]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b2e RCSB], [http://www.ebi.ac.uk/pdbsum/2b2e PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2e OCA], [https://pdbe.org/2b2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b2e RCSB], [https://www.ebi.ac.uk/pdbsum/2b2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b2e ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAPSD_BPMS2 CAPSD_BPMS2] Self-assembles to form the T=3 icosahedral virus shell that protects the viral nucleic acid. Acts as a translational repressor by binding with high specificity to a single stem-loop structure in the genomic RNA that contains the initiation codon of the gene for the viral replicase. Involved in virus assembly through the interaction between a capsid protein dimer and the multiple packaging signals present in the RNA genome.<ref>PMID:16531233</ref> <ref>PMID:18662904</ref> <ref>PMID:26608810</ref> <ref>PMID:8254664</ref> <ref>PMID:9245600</ref> <ref>PMID:9469847</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/2b2e_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/2b2e_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b2e ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2b2e" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Enterobacterio phage ms2]]
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[[Category: Escherichia phage MS2]]
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[[Category: Adams, C J.]]
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[[Category: Large Structures]]
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[[Category: Baron, A J.]]
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[[Category: Adams CJ]]
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[[Category: Grahn, E.]]
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[[Category: Baron AJ]]
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[[Category: Helgstrand, C.]]
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[[Category: Grahn E]]
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[[Category: Horn, W T.]]
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[[Category: Helgstrand C]]
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[[Category: Lago, H.]]
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[[Category: Horn WT]]
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[[Category: Liljas, L.]]
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[[Category: Lago H]]
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[[Category: Peabody, D S.]]
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[[Category: Liljas L]]
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[[Category: Phillips, S E.V.]]
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[[Category: Peabody DS]]
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[[Category: Stockley, P G.]]
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[[Category: Phillips SEV]]
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[[Category: Stonehouse, N J.]]
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[[Category: Stockley PG]]
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[[Category: Tars, K.]]
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[[Category: Stonehouse NJ]]
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[[Category: Capsid]]
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[[Category: Tars K]]
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[[Category: Hairpin]]
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[[Category: Levivirus]]
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[[Category: Protein/rna]]
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[[Category: Virus-viral protein-rna complex]]
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[[Category: Virus/viral]]
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Current revision

RNA stemloop from bacteriophage MS2 complexed with an N87S,E89K mutant MS2 capsid

PDB ID 2b2e

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