1huu

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[[Image:1huu.jpg|left|200px]]
 
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{{Structure
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==DNA-BINDING PROTEIN HU FROM BACILLUS STEAROTHERMOPHILUS==
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|PDB= 1huu |SIZE=350|CAPTION= <scene name='initialview01'>1huu</scene>, resolution 2.0&Aring;
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<StructureSection load='1huu' size='340' side='right'caption='[[1huu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1huu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HUU FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1huu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1huu OCA], [https://pdbe.org/1huu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1huu RCSB], [https://www.ebi.ac.uk/pdbsum/1huu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1huu ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''DNA-BINDING PROTEIN HU FROM BACILLUS STEAROTHERMOPHILUS'''
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[https://www.uniprot.org/uniprot/DBH_GEOSE DBH_GEOSE] Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The prokaryotic protein HU, integration host factor (IHF) from Escherichia coli, and transcription factor 1 (TF1) from bacteriophage SPO1 are closely related molecules. Biochemical results suggest that the role of these proteins is to bind and bend DNA. From the high-resolution structure of HU, we propose a model for this interaction with DNA. Crucial amino acid differences between the proteins can be rationalized in terms of their different specific functions.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hu/1huu_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1HUU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HUU OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1huu ConSurf].
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A protein structural motif that bends DNA., White SW, Appelt K, Wilson KS, Tanaka I, Proteins. 1989;5(4):281-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2508086 2508086]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Appelt, K.]]
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[[Category: Appelt K]]
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[[Category: Tanaka, I.]]
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[[Category: Tanaka I]]
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[[Category: White, S W.]]
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[[Category: White SW]]
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[[Category: Wilson, K S.]]
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[[Category: Wilson KS]]
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[[Category: alpha/beta class]]
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[[Category: dna supercoiling]]
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[[Category: dna-binding protein]]
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[[Category: minor groove binder]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:41:53 2008''
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Current revision

DNA-BINDING PROTEIN HU FROM BACILLUS STEAROTHERMOPHILUS

PDB ID 1huu

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