2b9c

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==Structure of tropomyosin's mid-region: bending and binding sites for actin==
==Structure of tropomyosin's mid-region: bending and binding sites for actin==
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<StructureSection load='2b9c' size='340' side='right' caption='[[2b9c]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='2b9c' size='340' side='right'caption='[[2b9c]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2b9c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B9C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2b9c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B9C FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b9c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b9c RCSB], [http://www.ebi.ac.uk/pdbsum/2b9c PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b9c OCA], [https://pdbe.org/2b9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b9c RCSB], [https://www.ebi.ac.uk/pdbsum/2b9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b9c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TPM1_RAT TPM1_RAT] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/2b9c_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/2b9c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b9c ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2b9c" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Tropomyosin|Tropomyosin]]
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*[[Tropomyosin 3D structures|Tropomyosin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Brown, J H.]]
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[[Category: Brown JH]]
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[[Category: Cohen, C.]]
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[[Category: Cohen C]]
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[[Category: Reshetnikova, L.]]
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[[Category: Reshetnikova L]]
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[[Category: Robinson, H.]]
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[[Category: Robinson H]]
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[[Category: Tobacman, L S.]]
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[[Category: Tobacman LS]]
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[[Category: Yammani, R D.]]
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[[Category: Yammani RD]]
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[[Category: Zhou, Z.]]
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[[Category: Zhou Z]]
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[[Category: Alanine]]
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[[Category: Alpha-helix]]
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[[Category: Axial stagger]]
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[[Category: Cardiomyopathy]]
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[[Category: Contractile protein]]
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[[Category: Crystal packing]]
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[[Category: Elongated protein]]
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[[Category: Radius]]
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[[Category: Side-chain packing]]
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[[Category: Temperature factor]]
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Current revision

Structure of tropomyosin's mid-region: bending and binding sites for actin

PDB ID 2b9c

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