2gth

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==crystal structure of the wildtype MHV coronavirus non-structural protein nsp15==
==crystal structure of the wildtype MHV coronavirus non-structural protein nsp15==
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<StructureSection load='2gth' size='340' side='right' caption='[[2gth]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='2gth' size='340' side='right'caption='[[2gth]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2gth]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Murine_hepatitis_virus_strain_a59 Murine hepatitis virus strain a59]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GTH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2gth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_hepatitis_virus_strain_A59 Murine hepatitis virus strain A59]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GTH FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gth OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gth RCSB], [http://www.ebi.ac.uk/pdbsum/2gth PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gth OCA], [https://pdbe.org/2gth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gth RCSB], [https://www.ebi.ac.uk/pdbsum/2gth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gth ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9J3E8_9BETC Q9J3E8_9BETC] The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.[ARBA:ARBA00003368]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/2gth_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/2gth_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gth ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2gth" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Murine hepatitis virus strain a59]]
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[[Category: Large Structures]]
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[[Category: Lou, Z.]]
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[[Category: Murine hepatitis virus strain A59]]
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[[Category: Rao, Z.]]
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[[Category: Lou Z]]
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[[Category: Su, D.]]
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[[Category: Rao Z]]
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[[Category: Sun, F.]]
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[[Category: Su D]]
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[[Category: Xu, X.]]
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[[Category: Sun F]]
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[[Category: Zhai, Y.]]
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[[Category: Xu X]]
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[[Category: Mhv]]
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[[Category: Zhai Y]]
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[[Category: Nsp15]]
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[[Category: Viral protein]]
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Current revision

crystal structure of the wildtype MHV coronavirus non-structural protein nsp15

PDB ID 2gth

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