2ker
From Proteopedia
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==alpha-amylase inhibitor Parvulustat (Z-2685) from Streptomyces parvulus== | ==alpha-amylase inhibitor Parvulustat (Z-2685) from Streptomyces parvulus== | ||
| - | <StructureSection load='2ker' size='340' side='right' caption='[[2ker]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2ker' size='340' side='right'caption='[[2ker]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ker]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2ker]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_12434 Atcc 12434]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KER FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ker FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ker OCA], [https://pdbe.org/2ker PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ker RCSB], [https://www.ebi.ac.uk/pdbsum/2ker PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ker ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/IAA_STRRO IAA_STRRO]] Inhibits mammalian alpha-amylases specifically but has no action on plant and microbial alpha-amylases. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ke/2ker_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ke/2ker_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ker ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2ker" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Atcc 12434]] |
| - | [[Category: Engels, J W | + | [[Category: Large Structures]] |
| - | [[Category: Han, S | + | [[Category: Engels, J W]] |
| - | [[Category: Hassani, I | + | [[Category: Han, S]] |
| - | [[Category: Jonker, H R.A | + | [[Category: Hassani, I]] |
| - | [[Category: Rehm, S | + | [[Category: Jonker, H R.A]] |
| - | [[Category: Schwalbe, H | + | [[Category: Rehm, S]] |
| - | [[Category: Sokocevic, A | + | [[Category: Schwalbe, H]] |
| + | [[Category: Sokocevic, A]] | ||
[[Category: Alpha-amylase inhibitor]] | [[Category: Alpha-amylase inhibitor]] | ||
[[Category: Hydrolase inhibitor]] | [[Category: Hydrolase inhibitor]] | ||
Current revision
alpha-amylase inhibitor Parvulustat (Z-2685) from Streptomyces parvulus
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