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2hm8
From Proteopedia
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==Solution Structure of the C-terminal MA-3 domain of Pdcd4== | ==Solution Structure of the C-terminal MA-3 domain of Pdcd4== | ||
| - | <StructureSection load='2hm8' size='340' side='right' caption='[[2hm8 | + | <StructureSection load='2hm8' size='340' side='right'caption='[[2hm8]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2hm8]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2hm8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HM8 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hm8 OCA], [https://pdbe.org/2hm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hm8 RCSB], [https://www.ebi.ac.uk/pdbsum/2hm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hm8 ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE] Note=Decreases benign tumor development and malignant progression. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.<ref>PMID:12482958</ref> <ref>PMID:12894233</ref> <ref>PMID:16024603</ref> <ref>PMID:17060447</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hm/2hm8_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hm/2hm8_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hm8 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2hm8" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Cell death protein|Cell death protein]] | + | *[[Cell death protein 3D structures|Cell death protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Bohm | + | [[Category: Bohm M]] |
| - | [[Category: Carr | + | [[Category: Carr MD]] |
| - | [[Category: Choong | + | [[Category: Choong PT]] |
| - | [[Category: Klempnauer | + | [[Category: Klempnauer KH]] |
| - | [[Category: Muskett | + | [[Category: Muskett FW]] |
| - | [[Category: Veverka | + | [[Category: Veverka V]] |
| - | [[Category: Waters | + | [[Category: Waters LC]] |
| - | + | ||
| - | + | ||
Current revision
Solution Structure of the C-terminal MA-3 domain of Pdcd4
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Categories: Large Structures | Mus musculus | Bohm M | Carr MD | Choong PT | Klempnauer KH | Muskett FW | Veverka V | Waters LC
