2jaa
From Proteopedia
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| - | == | + | |
| - | <StructureSection load='2jaa' size='340' side='right' caption='[[2jaa]], [[Resolution|resolution]] 3.10Å' scene=''> | + | ==SeMet substituted Shigella Flexneri Ipad== |
| + | <StructureSection load='2jaa' size='340' side='right'caption='[[2jaa]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2jaa]] is a 2 chain structure | + | <table><tr><td colspan='2'>[[2jaa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JAA FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2j0n|2j0n]], [[2j0o|2j0o]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2j0n|2j0n]], [[2j0o|2j0o]]</div></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jaa OCA], [https://pdbe.org/2jaa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jaa RCSB], [https://www.ebi.ac.uk/pdbsum/2jaa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jaa ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/IPAD_SHIFL IPAD_SHIFL]] Required for bacterial invasion of host cells. Controls IpaB and IpaC secretion, and the efficiency with which they are physically inserted into target cell membranes. These proteins are exported via TTSS to form a pore in the host membrane that allows the translocation of the other effectors into the host cytoplasm. Along with IpaB, is essential for both blocking secretion through the Mxi/Spa translocon in the absence of a secretion-inducing signal, and for controlling the level of secretion in the presence of this signal.<ref>PMID:7957095</ref> <ref>PMID:15731041</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2jaa_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2jaa_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jaa ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2jaa" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Birket, S | + | [[Category: Birket, S]] |
| - | [[Category: Blocker, A J | + | [[Category: Blocker, A J]] |
| - | [[Category: Deane, J E | + | [[Category: Deane, J E]] |
| - | [[Category: Espina, M | + | [[Category: Espina, M]] |
| - | [[Category: Field, T | + | [[Category: Field, T]] |
| - | [[Category: Galyov, E E | + | [[Category: Galyov, E E]] |
| - | [[Category: Johnson, S | + | [[Category: Johnson, S]] |
| - | [[Category: Lea, S M | + | [[Category: Lea, S M]] |
| - | [[Category: Olive, A | + | [[Category: Olive, A]] |
| - | [[Category: Picking, W D | + | [[Category: Picking, W D]] |
| - | [[Category: Picking, W L | + | [[Category: Picking, W L]] |
| - | [[Category: Roversi, P | + | [[Category: Roversi, P]] |
[[Category: Cell invasion]] | [[Category: Cell invasion]] | ||
[[Category: Invasin]] | [[Category: Invasin]] | ||
Current revision
SeMet substituted Shigella Flexneri Ipad
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Categories: Large Structures | Birket, S | Blocker, A J | Deane, J E | Espina, M | Field, T | Galyov, E E | Johnson, S | Lea, S M | Olive, A | Picking, W D | Picking, W L | Roversi, P | Cell invasion | Invasin | Ipad | Semet | Shigella flexneri | T3ss | Type iii secretion | Virulence
