2qu4
From Proteopedia
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==Model for Bacterial ParM Filament== | ==Model for Bacterial ParM Filament== | ||
| - | < | + | <SX load='2qu4' size='340' side='right' viewer='molstar' caption='[[2qu4]], [[Resolution|resolution]] 16.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2qu4]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2qu4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QU4 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 16Å</td></tr> |
| - | <table> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qu4 OCA], [https://pdbe.org/2qu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qu4 RCSB], [https://www.ebi.ac.uk/pdbsum/2qu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qu4 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PARM_ECOLX PARM_ECOLX] Involved in the control of plasmid partition. Required for the accurate segregation of the plasmid. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qu/2qu4_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qu/2qu4_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qu4 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Bacterial ParM is a homolog of eukaryotic actin and is involved in moving plasmids so that they segregate properly during cell division. Using cryo-EM and three-dimensional reconstruction, we show that ParM filaments have a different structure from F-actin, with very different subunit-subunit interfaces. These interfaces result in the helical handedness of the ParM filament being opposite to that of F-actin. Like F-actin, ParM filaments have a variable twist, and we show that this involves domain-domain rotations within the ParM subunit. The present results yield new insights into polymorphisms within F-actin, as well as the evolution of polymer families. | ||
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| - | The structure of bacterial ParM filaments.,Orlova A, Garner EC, Galkin VE, Heuser J, Mullins RD, Egelman EH Nat Struct Mol Biol. 2007 Oct;14(10):921-6. Epub 2007 Sep 16. PMID:17873883<ref>PMID:17873883</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Plasmid segregation protein ParM|Plasmid segregation protein ParM]] | |
| - | == | + | |
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__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Egelman | + | [[Category: Large Structures]] |
| - | [[Category: Galkin | + | [[Category: Egelman EH]] |
| - | [[Category: Garner | + | [[Category: Galkin VE]] |
| - | [[Category: Heuser | + | [[Category: Garner EC]] |
| - | [[Category: Mullins | + | [[Category: Heuser J]] |
| - | [[Category: Orlova | + | [[Category: Mullins RD]] |
| - | + | [[Category: Orlova A]] | |
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Current revision
Model for Bacterial ParM Filament
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