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2r53

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==Crystal structure analysis of Bone Morphogenetic Protein-6 variant B2 (B2-BMP-6)==
==Crystal structure analysis of Bone Morphogenetic Protein-6 variant B2 (B2-BMP-6)==
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<StructureSection load='2r53' size='340' side='right' caption='[[2r53]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='2r53' size='340' side='right'caption='[[2r53]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2r53]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R53 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R53 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2r53]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R53 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bmp|3bmp]], [[1rew|1rew]], [[2h62|2h62]], [[2h64|2h64]], [[2r52|2r52]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BMP6, VGR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r53 OCA], [https://pdbe.org/2r53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r53 RCSB], [https://www.ebi.ac.uk/pdbsum/2r53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r53 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r53 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r53 RCSB], [http://www.ebi.ac.uk/pdbsum/2r53 PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/BMP6_HUMAN BMP6_HUMAN] Induces cartilage and bone formation.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r53_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r53_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r53 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2r53" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Bone morphogenetic protein 3D structures|Bone morphogenetic protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Mueller, T D.]]
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[[Category: Large Structures]]
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[[Category: Sebald, W.]]
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[[Category: Mueller TD]]
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[[Category: Bmp6]]
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[[Category: Sebald W]]
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[[Category: Chondrogenesis]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Cytokine]]
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[[Category: Developmental protein]]
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[[Category: Differentiation]]
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[[Category: Glycoprotein]]
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[[Category: Growth factor]]
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[[Category: Osteogenesis]]
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[[Category: Secreted]]
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[[Category: Tgf-beta ligand]]
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[[Category: Vgr]]
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Current revision

Crystal structure analysis of Bone Morphogenetic Protein-6 variant B2 (B2-BMP-6)

PDB ID 2r53

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