2vo0

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==STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH C-(4-(4-CHLOROPHENYL)-1-(7H-PYRROLO(2,3-D)PYRIMIDIN-4-YL)PIPERIDIN-4-YL)METHYLAMINE==
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<StructureSection load='2vo0' size='340' side='right' caption='[[2vo0]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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==Structure of PKA-PKB chimera complexed with C-(4-(4-Chlorophenyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-yl)methylamine==
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<StructureSection load='2vo0' size='340' side='right'caption='[[2vo0]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vo0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VO0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VO0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vo0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VO0 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=M03:1-[4-(4-CHLOROPHENYL)-1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL]METHANAMINE'>M03</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=M03:1-[4-(4-CHLOROPHENYL)-1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL]METHANAMINE'>M03</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xh6|1xh6]], [[1xh9|1xh9]], [[2vnw|2vnw]], [[1ydr|1ydr]], [[2uvz|2uvz]], [[1xh4|1xh4]], [[1sve|1sve]], [[2uvx|2uvx]], [[2f7e|2f7e]], [[1q8u|1q8u]], [[1kmu|1kmu]], [[1cmk|1cmk]], [[2uw7|2uw7]], [[1q62|1q62]], [[2jds|2jds]], [[2uw8|2uw8]], [[2gnf|2gnf]], [[2uzu|2uzu]], [[2uw3|2uw3]], [[2c1a|2c1a]], [[1smh|1smh]], [[2uw4|2uw4]], [[1veb|1veb]], [[2c1b|2c1b]], [[2gnl|2gnl]], [[1jlu|1jlu]], [[1xh7|1xh7]], [[2uzv|2uzv]], [[1q24|1q24]], [[2uw6|2uw6]], [[1svg|1svg]], [[1kmw|1kmw]], [[1xha|1xha]], [[2gnj|2gnj]], [[2uvy|2uvy]], [[2gnh|2gnh]], [[1szm|1szm]], [[2gfc|2gfc]], [[1q61|1q61]], [[2gng|2gng]], [[1ydt|1ydt]], [[2uzt|2uzt]], [[1q8w|1q8w]], [[1svh|1svh]], [[2uzw|2uzw]], [[2uw0|2uw0]], [[2jdv|2jdv]], [[2uw5|2uw5]], [[2gni|2gni]], [[1xh5|1xh5]], [[1yds|1yds]], [[1stc|1stc]], [[2jdt|2jdt]], [[1q8t|1q8t]], [[1xh8|1xh8]], [[2vo3|2vo3]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vo0 OCA], [https://pdbe.org/2vo0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vo0 RCSB], [https://www.ebi.ac.uk/pdbsum/2vo0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vo0 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vo0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vo0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vo0 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2vo0_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2vo0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vo0 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2vo0" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[CAMP-dependent protein kinase|CAMP-dependent protein kinase]]
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*[[CAMP-dependent protein kinase 3D structures|CAMP-dependent protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: CAMP-dependent protein kinase]]
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[[Category: Homo sapiens]]
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[[Category: Aherne, G W.]]
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[[Category: Large Structures]]
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[[Category: Caldwell, J J.]]
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[[Category: Aherne GW]]
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[[Category: Collins, I.]]
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[[Category: Caldwell JJ]]
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[[Category: Davies, T G.]]
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[[Category: Collins I]]
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[[Category: Donald, A.]]
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[[Category: Davies TG]]
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[[Category: Garrett, M D.]]
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[[Category: Donald A]]
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[[Category: Hunter, L K.]]
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[[Category: Garrett MD]]
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[[Category: Mchardy, T.]]
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[[Category: Hunter LK]]
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[[Category: Raynaud, F I.]]
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[[Category: McHardy T]]
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[[Category: Rowlands, M G.]]
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[[Category: Raynaud FI]]
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[[Category: Ruddle, R.]]
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[[Category: Rowlands MG]]
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[[Category: Taylor, K.]]
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[[Category: Ruddle R]]
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[[Category: Verdonk, M.]]
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[[Category: Taylor K]]
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[[Category: Workman, P.]]
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[[Category: Verdonk M]]
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[[Category: Atp-binding]]
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[[Category: Workman P]]
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[[Category: Camp]]
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[[Category: Kinase]]
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[[Category: Lipoprotein]]
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[[Category: Myristate]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein kinase inhibitor]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]
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Current revision

Structure of PKA-PKB chimera complexed with C-(4-(4-Chlorophenyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-yl)methylamine

PDB ID 2vo0

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