This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ihv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:41, 29 November 2023) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1ihv.gif|left|200px]]
 
-
{{Structure
+
==SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, MINIMIZED AVERAGE STRUCTURE==
-
|PDB= 1ihv |SIZE=350|CAPTION= <scene name='initialview01'>1ihv</scene>
+
<StructureSection load='1ihv' size='340' side='right'caption='[[1ihv]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1ihv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IHV FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ihv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ihv OCA], [https://pdbe.org/1ihv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ihv RCSB], [https://www.ebi.ac.uk/pdbsum/1ihv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ihv ProSAT]</span></td></tr>
-
}}
+
</table>
-
 
+
== Function ==
-
'''SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, MINIMIZED AVERAGE STRUCTURE'''
+
[https://www.uniprot.org/uniprot/POL_HV1Z6 POL_HV1Z6] Integrase performs the integration of the newly synthesized dsDNA copy of the viral genome into the host chromosome. The integrated DNA is called provirus.
-
 
+
<div style="background-color:#fffaf0;">
-
 
+
== Publication Abstract from PubMed ==
-
==Overview==
+
The solution structure of the DNA binding domain of HIV-1 integrase (residues 220-270) has been determined by multidimensional NMR spectroscopy. The protein is a dimer in solution, and each subunit is composed of a five-stranded beta-barrel with a topology very similar to that of the SH3 domain. The dimer is formed by a stacked beta-interface comprising strands 2, 3, and 4, with the two triple-stranded antiparallel beta-sheets, one from each subunit, oriented antiparallel to each other. One surface of the dimer, bounded by the loop between strands beta 1 and beta 2, forms a saddle-shaped groove with dimensions of approximately 24 x 23 x 12 A in cross section. Lys264, which has been shown from mutational data to be involved in DNA binding, protrudes from this surface, implicating the saddle-shaped groove as the potential DNA binding site.
The solution structure of the DNA binding domain of HIV-1 integrase (residues 220-270) has been determined by multidimensional NMR spectroscopy. The protein is a dimer in solution, and each subunit is composed of a five-stranded beta-barrel with a topology very similar to that of the SH3 domain. The dimer is formed by a stacked beta-interface comprising strands 2, 3, and 4, with the two triple-stranded antiparallel beta-sheets, one from each subunit, oriented antiparallel to each other. One surface of the dimer, bounded by the loop between strands beta 1 and beta 2, forms a saddle-shaped groove with dimensions of approximately 24 x 23 x 12 A in cross section. Lys264, which has been shown from mutational data to be involved in DNA binding, protrudes from this surface, implicating the saddle-shaped groove as the potential DNA binding site.
-
==About this Structure==
+
Solution structure of the DNA binding domain of HIV-1 integrase.,Lodi PJ, Ernst JA, Kuszewski J, Hickman AB, Engelman A, Craigie R, Clore GM, Gronenborn AM Biochemistry. 1995 Aug 8;34(31):9826-33. PMID:7632683<ref>PMID:7632683</ref>
-
1IHV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHV OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
Solution structure of the DNA binding domain of HIV-1 integrase., Lodi PJ, Ernst JA, Kuszewski J, Hickman AB, Engelman A, Craigie R, Clore GM, Gronenborn AM, Biochemistry. 1995 Aug 8;34(31):9826-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7632683 7632683]
+
</div>
-
[[Category: Human immunodeficiency virus]]
+
<div class="pdbe-citations 1ihv" style="background-color:#fffaf0;"></div>
-
[[Category: Single protein]]
+
-
[[Category: Clore, G M.]]
+
-
[[Category: Ernst, J A.]]
+
-
[[Category: Gronenborn, A M.]]
+
-
[[Category: Lodi, P J.]]
+
-
[[Category: aid]]
+
-
[[Category: dna-binding protein]]
+
-
[[Category: polyprotein]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:50:32 2008''
+
==See Also==
 +
*[[Retroviral integrase 3D structures|Retroviral integrase 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Human immunodeficiency virus 1]]
 +
[[Category: Large Structures]]
 +
[[Category: Clore GM]]
 +
[[Category: Ernst JA]]
 +
[[Category: Gronenborn AM]]
 +
[[Category: Lodi PJ]]

Current revision

SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1ihv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ihv"
Personal tools