2vuc

==PA-IIL LECTIN FROM PSEUDOMONAS AERUGINOSA COMPLEXED WITH FUCOSE-DERIVED GLYCOMIMETICS==

<StructureSection load='2vuc' size='340' side='right' caption='[[2vuc]], [[Resolution|resolution]] 1.30&Aring;' scene=''>

<table><tr><td colspan='2'>[[2vuc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VUC FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YX0:[(3E)-3-(1-HYDROXYETHYLIDENE)-2,3-DIHYDROISOXAZOL-5-YL]METHYL+6-DEOXY-ALPHA-L-GALACTOPYRANOSIDE'>YX0</scene><br>

<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ovs|1ovs]], [[1oxc|1oxc]], [[1w8f|1w8f]], [[2jdk|2jdk]], [[1oux|1oux]], [[1gzt|1gzt]], [[2jdh|2jdh]], [[2jdy|2jdy]], [[1ous|1ous]], [[2jdu|2jdu]], [[1ovp|1ovp]], [[2jdp|2jdp]], [[1our|1our]], [[1uzv|1uzv]], [[2boj|2boj]], [[2bp6|2bp6]], [[2jdm|2jdm]], [[2jdn|2jdn]], [[1w43|1w43]], [[1w8h|1w8h]], [[2vud|2vud]]</td></tr>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vuc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vuc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vuc RCSB], [http://www.ebi.ac.uk/pdbsum/2vuc PDBsum]</span></td></tr>

<table>

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vu/2vuc_consurf.spt"</scriptWhenChecked>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

Pseudomonas aeruginosa galactose- and fucose-binding lectins (PA-IL and PA-IIL) contribute to the virulence of this pathogenic bacterium, which is a major cause of morbidity and mortality in cystic fibrosis patients. The crystal structure of PA-IIL in complex with fucose reveals a tetrameric structure. Each monomer displays a nine-stranded, antiparallel b-sandwich arrangement and contains two close calcium cations that mediate the binding of fucose in a recognition mode unique among carbohydrate-protein interactions. Experimental binding studies, together with theoretical docking of fucose-containing oligosaccharides, are consistent with the assumption that antigens of the Lewis a (Le(a)) series may be the preferred ligands of this lectin. Precise knowledge of the lectin-binding site should allow a better design of new antibacterial-adhesion prophylactics.

Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients.,Mitchell E, Houles C, Sudakevitz D, Wimmerova M, Gautier C, Perez S, Wu AM, Gilboa-Garber N, Imberty A Nat Struct Biol. 2002 Dec;9(12):918-21. PMID:12415289<ref>PMID:12415289</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

</div>

== References ==

<references/>

[[Category: Beha, S.]]

[[Category: Imberty, A.]]

[[Category: Marotte, K.]]

[[Category: Mitchell, E P.]]

[[Category: Roy, R.]]

[[Category: Sabin, C.]]

[[Category: Sugar-binding protein]]