2w0t
From Proteopedia
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| - | == | + | |
| - | <StructureSection load='2w0t' size='340' side='right' caption='[[2w0t]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | ==Solution structure of the FCS zinc finger domain of human LMBL2== |
| + | <StructureSection load='2w0t' size='340' side='right'caption='[[2w0t]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2w0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2w0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2W0T FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0t OCA], [http://pdbe.org/2w0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w0t RCSB], [http://www.ebi.ac.uk/pdbsum/2w0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w0t ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LMBL2_HUMAN LMBL2_HUMAN]] Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.<ref>PMID:19233876</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w0/2w0t_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w0/2w0t_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w0t ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2w0t" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
| - | [[Category: Allen, M D | + | [[Category: Large Structures]] |
| - | [[Category: Bycroft, M | + | [[Category: Allen, M D]] |
| - | [[Category: Lechtenberg, B C | + | [[Category: Bycroft, M]] |
| + | [[Category: Lechtenberg, B C]] | ||
| + | [[Category: Alternative splicing]] | ||
[[Category: Chromatin regulator]] | [[Category: Chromatin regulator]] | ||
[[Category: Lmbl2]] | [[Category: Lmbl2]] | ||
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[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Polycomb group]] | [[Category: Polycomb group]] | ||
| + | [[Category: Polymorphism]] | ||
[[Category: Rna binding]] | [[Category: Rna binding]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
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[[Category: Treble clef fold]] | [[Category: Treble clef fold]] | ||
[[Category: Yacg]] | [[Category: Yacg]] | ||
| + | [[Category: Zinc]] | ||
[[Category: Zinc-finger]] | [[Category: Zinc-finger]] | ||
Current revision
Solution structure of the FCS zinc finger domain of human LMBL2
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Categories: Human | Large Structures | Allen, M D | Bycroft, M | Lechtenberg, B C | Alternative splicing | Chromatin regulator | Lmbl2 | Mbt repeat | Metal-binding | Mym zinc finger | Nucleus | Pcg protein | Phosphoprotein | Polycomb group | Polymorphism | Rna binding | Transcription | Transcription regulation | Treble clef fold | Yacg | Zinc | Zinc-finger
