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2uz6

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==AChBP-targeted a-conotoxin correlates distinct binding orientations with nAChR subtype selectivity.==
==AChBP-targeted a-conotoxin correlates distinct binding orientations with nAChR subtype selectivity.==
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<StructureSection load='2uz6' size='340' side='right' caption='[[2uz6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='2uz6' size='340' side='right'caption='[[2uz6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2uz6]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UZ6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2uz6]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica] and [https://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UZ6 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2br7|2br7]], [[2br8|2br8]], [[2byn|2byn]], [[2byp|2byp]], [[2byq|2byq]], [[2byr|2byr]], [[2bys|2bys]], [[2c9t|2c9t]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz6 OCA], [https://pdbe.org/2uz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2uz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uz6 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uz6 RCSB], [http://www.ebi.ac.uk/pdbsum/2uz6 PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8WSF8_APLCA Q8WSF8_APLCA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/2uz6_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/2uz6_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uz6 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2uz6" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Acetylcholine binding protein|Acetylcholine binding protein]]
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*[[Acetylcholine binding protein 3D structures|Acetylcholine binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Aplysia californica]]
[[Category: Aplysia californica]]
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[[Category: Alewood, P F.]]
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[[Category: Conus textile]]
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[[Category: Buttner, R.]]
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[[Category: Large Structures]]
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[[Category: Dutertre, S.]]
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[[Category: Alewood PF]]
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[[Category: Elk, R Van.]]
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[[Category: Buttner R]]
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[[Category: Fish, A.]]
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[[Category: Dutertre S]]
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[[Category: Hopping, G.]]
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[[Category: Fish A]]
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[[Category: Kendel, Y.]]
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[[Category: Hopping G]]
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[[Category: Lewis, R J.]]
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[[Category: Kendel Y]]
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[[Category: Nicke, A.]]
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[[Category: Lewis RJ]]
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[[Category: Schroeder, C.]]
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[[Category: Nicke A]]
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[[Category: Sixma, T K.]]
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[[Category: Schroeder C]]
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[[Category: Smit, A B.]]
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[[Category: Sixma TK]]
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[[Category: Ulens, C.]]
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[[Category: Smit AB]]
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[[Category: Receptor-toxin complex]]
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[[Category: Ulens C]]
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[[Category: Van Elk R]]

Current revision

AChBP-targeted a-conotoxin correlates distinct binding orientations with nAChR subtype selectivity.

PDB ID 2uz6

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