2vt1

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==CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF SPA40, THE SPECIFICITY SWITCH FOR THE SHIGELLA FLEXNERI TYPE III SECRETION SYSTEM==
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<StructureSection load='2vt1' size='340' side='right' caption='[[2vt1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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==Crystal structure of the cytoplasmic domain of Spa40, the specificity switch for the Shigella flexneri Type III Secretion System==
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<StructureSection load='2vt1' size='340' side='right'caption='[[2vt1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vt1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VT1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vt1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VT1 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vt1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vt1 RCSB], [http://www.ebi.ac.uk/pdbsum/2vt1 PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vt1 OCA], [https://pdbe.org/2vt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vt1 RCSB], [https://www.ebi.ac.uk/pdbsum/2vt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vt1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPAS_SHIFL SPAS_SHIFL] Required for surface presentation of invasion plasmid antigens. Could play a role in preserving the translocation competence of the ipa antigens. Required for invasion and for secretion of the three ipa proteins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vt/2vt1_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vt/2vt1_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vt1 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2vt1" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Shigella flexneri]]
[[Category: Shigella flexneri]]
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[[Category: Deane, J E.]]
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[[Category: Deane JE]]
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[[Category: Flot, D.]]
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[[Category: Flot D]]
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[[Category: Graham, S C.]]
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[[Category: Graham SC]]
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[[Category: Johnson, S.]]
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[[Category: Johnson S]]
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[[Category: Lea, S M.]]
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[[Category: Lea SM]]
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[[Category: Mitchell, E P.]]
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[[Category: Mitchell EP]]
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[[Category: Flhb]]
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[[Category: Inner membrane]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Shigella flexneri]]
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[[Category: Spa40]]
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[[Category: Specificity switch]]
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[[Category: T3ss]]
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[[Category: Transmembrane]]
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[[Category: Type iii secretion system]]
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[[Category: Virulence]]
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[[Category: Yscu]]
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Current revision

Crystal structure of the cytoplasmic domain of Spa40, the specificity switch for the Shigella flexneri Type III Secretion System

PDB ID 2vt1

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OCA

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