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2wzl

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==THE STRUCTURE OF THE N-RNA BINDING DOMAIN OF THE MOKOLA VIRUS PHOSPHOPROTEIN==
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<StructureSection load='2wzl' size='340' side='right' caption='[[2wzl]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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==The Structure of the N-RNA Binding Domain of the Mokola virus Phosphoprotein==
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<StructureSection load='2wzl' size='340' side='right'caption='[[2wzl]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mokola_virus Mokola virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WZL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wzl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mokola_lyssavirus Mokola lyssavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WZL FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wzl RCSB], [http://www.ebi.ac.uk/pdbsum/2wzl PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzl OCA], [https://pdbe.org/2wzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wzl RCSB], [https://www.ebi.ac.uk/pdbsum/2wzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PHOSP_MOKV PHOSP_MOKV] Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/2wzl_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/2wzl_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wzl ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2wzl" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Mokola virus]]
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[[Category: Large Structures]]
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[[Category: Assenberg, R.]]
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[[Category: Mokola lyssavirus]]
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[[Category: Bourhy, H.]]
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[[Category: Assenberg R]]
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[[Category: Delmas, O.]]
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[[Category: Bourhy H]]
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[[Category: Graham, S.]]
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[[Category: Delmas O]]
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[[Category: Grimes, J.]]
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[[Category: Graham S]]
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[[Category: Larrous, F.]]
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[[Category: Grimes J]]
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[[Category: Ren, J.]]
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[[Category: Larrous F]]
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[[Category: Tangy, F.]]
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[[Category: Ren J]]
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[[Category: Verma, A.]]
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[[Category: Tangy F]]
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[[Category: Vidalain, P.]]
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[[Category: Verma A]]
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[[Category: Chaperone]]
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[[Category: Vidalain P]]
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[[Category: Nucleoprotein]]
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[[Category: Rabies]]
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[[Category: Rna replication]]
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[[Category: Viral protein]]
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[[Category: Virion]]
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Current revision

The Structure of the N-RNA Binding Domain of the Mokola virus Phosphoprotein

PDB ID 2wzl

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