2v9a

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==STRUCTURE OF CITRATE-FREE PERIPLASMIC DOMAIN OF SENSOR HISTIDINE KINASE CITA==
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<StructureSection load='2v9a' size='340' side='right' caption='[[2v9a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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==Structure of Citrate-free Periplasmic Domain of Sensor Histidine Kinase CitA==
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<StructureSection load='2v9a' size='340' side='right'caption='[[2v9a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2v9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V9A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2v9a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V9A FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1p0z|1p0z]], [[2j80|2j80]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9a OCA], [https://pdbe.org/2v9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v9a RCSB], [https://www.ebi.ac.uk/pdbsum/2v9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v9a ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v9a RCSB], [http://www.ebi.ac.uk/pdbsum/2v9a PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/CITA_KLEPN CITA_KLEPN] Member of the two-component regulatory system CitA/CitB. Probably activates CitB by phosphorylation. The periplasmic domain binds H-citrate(2-), which is essential for induction of the citrate-fermentation genes.<ref>PMID:10447894</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v9/2v9a_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v9/2v9a_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v9a ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2v9a" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Histidine kinase]]
 
[[Category: Klebsiella pneumoniae]]
[[Category: Klebsiella pneumoniae]]
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[[Category: Becker, S.]]
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[[Category: Large Structures]]
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[[Category: Bott, M.]]
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[[Category: Becker S]]
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[[Category: Griesinger, C.]]
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[[Category: Bott M]]
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[[Category: Madden, D R.]]
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[[Category: Griesinger C]]
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[[Category: Reinelt, S.]]
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[[Category: Madden DR]]
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[[Category: Sevvana, M.]]
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[[Category: Reinelt S]]
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[[Category: Sheldrick, G M.]]
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[[Category: Sevvana M]]
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[[Category: Vijayan, V.]]
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[[Category: Sheldrick GM]]
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[[Category: Zweckstetter, M.]]
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[[Category: Vijayan V]]
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[[Category: Cita]]
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[[Category: Zweckstetter M]]
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[[Category: Inner membrane]]
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[[Category: Kinase]]
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[[Category: Membrane]]
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[[Category: Phosphorylation]]
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[[Category: Sensor domain]]
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[[Category: Sensor histidine kinase]]
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[[Category: Signal transduction]]
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[[Category: Transferase]]
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[[Category: Transmembrane]]
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[[Category: Two-component regulatory system]]
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Current revision

Structure of Citrate-free Periplasmic Domain of Sensor Histidine Kinase CitA

PDB ID 2v9a

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