4v10
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Skelemin Association with alpha2b,beta3 Integrin: A Structural Model== | |
| + | <StructureSection load='4v10' size='340' side='right'caption='[[4v10]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4v10]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V10 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v10 OCA], [https://pdbe.org/4v10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v10 RCSB], [https://www.ebi.ac.uk/pdbsum/4v10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v10 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MYOM1_MOUSE MYOM1_MOUSE] May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. May also contact myosin filaments. Also binds beta-integrins. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Over the last two decades, our knowledge concerning intracellular events that regulate integrin's affinity to their soluble ligands has significantly improved. However, the mechanism of adhesion-induced integrin clustering and development of focal complexes, which could further mature to form focal adhesions, still remains under-investigated. Here we present a structural model of tandem IgC2 domains of skelemin in complex with the cytoplasmic tails of integrin alphaIIbbeta3. The model is generated based upon NMR data and this tertiary assembly illuminates a potential link between the essential cell adhesion receptors and myosin filaments. This connection may serve as a basis for generating the mechanical forces necessary for cell migration and remodeling. | ||
| - | + | Skelemin Association with AlphaIIbBeta3 Integrin: A Structural Model.,Gorbatyuk V, Nguyen K, Podolnikova NP, Deshmukh L, Lin X, Ugarova TP, Vinogradova O Biochemistry. 2014 Sep 15. PMID:25224262<ref>PMID:25224262</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4v10" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Myomesin|Myomesin]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Deshmukh L]] | ||
| + | [[Category: Gorbatyuk V]] | ||
| + | [[Category: Nguyen K]] | ||
| + | [[Category: Vinogradova O]] | ||
Current revision
Skelemin Association with alpha2b,beta3 Integrin: A Structural Model
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