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1iou

From Proteopedia

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[[Image:1iou.gif|left|200px]]
 
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{{Structure
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==SOLUTION STRUCTURE OF YKT6P (1-140)==
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|PDB= 1iou |SIZE=350|CAPTION= <scene name='initialview01'>1iou</scene>
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<StructureSection load='1iou' size='340' side='right'caption='[[1iou]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1iou]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IOU FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iou OCA], [https://pdbe.org/1iou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iou RCSB], [https://www.ebi.ac.uk/pdbsum/1iou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iou ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''SOLUTION STRUCTURE OF YKT6P (1-140)'''
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[https://www.uniprot.org/uniprot/YKT6_YEAST YKT6_YEAST]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/io/1iou_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iou ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
Ykt6p is a nonsyntaxin SNARE implicated in multiple intracellular membrane trafficking steps. Here we present the structure of the NH2-terminal domain of Ykt6p (Ykt6pN, residues 1 to 140). The structure of Ykt6pN differed entirely from that of syntaxin and resembled the overall fold of the actin regulatory protein, profilin. Like some syntaxins, Ykt6p adopted a folded back conformation in which Ykt6pN bound to its COOH-terminal core domain. The NH2-terminal domain plays an important biological role in the function of Ykt6p, which in vitro studies revealed to include influencing the kinetics and proper assembly of SNARE complexes.
Ykt6p is a nonsyntaxin SNARE implicated in multiple intracellular membrane trafficking steps. Here we present the structure of the NH2-terminal domain of Ykt6p (Ykt6pN, residues 1 to 140). The structure of Ykt6pN differed entirely from that of syntaxin and resembled the overall fold of the actin regulatory protein, profilin. Like some syntaxins, Ykt6p adopted a folded back conformation in which Ykt6pN bound to its COOH-terminal core domain. The NH2-terminal domain plays an important biological role in the function of Ykt6p, which in vitro studies revealed to include influencing the kinetics and proper assembly of SNARE complexes.
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==About this Structure==
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An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p.,Tochio H, Tsui MM, Banfield DK, Zhang M Science. 2001 Jul 27;293(5530):698-702. PMID:11474112<ref>PMID:11474112</ref>
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1IOU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IOU OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p., Tochio H, Tsui MM, Banfield DK, Zhang M, Science. 2001 Jul 27;293(5530):698-702. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11474112 11474112]
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</div>
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<div class="pdbe-citations 1iou" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Banfield DK]]
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[[Category: Banfield, D K.]]
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[[Category: Tochio H]]
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[[Category: Tochio, H.]]
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[[Category: Tsui MMK]]
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[[Category: Tsui, M M.K.]]
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[[Category: Zhang M]]
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[[Category: Zhang, M.]]
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[[Category: snare]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:53:02 2008''
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Current revision

SOLUTION STRUCTURE OF YKT6P (1-140)

PDB ID 1iou

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OCA

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