2xcr
From Proteopedia
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| - | == | + | |
| - | <StructureSection load='2xcr' size='340' side='right' caption='[[2xcr]], [[Resolution|resolution]] 3.50Å' scene=''> | + | ==The 3.5A crystal structure of the catalytic core (B'A' region) of Staphylococcus aureus DNA Gyrase complexed with GSK299423 and DNA== |
| + | <StructureSection load='2xcr' size='340' side='right'caption='[[2xcr]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2xcr]] is a 8 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2xcr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XCR FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5Å</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5UA:5-O-CARBOXY-2-DEOXYADENOSINE'>5UA</scene>, <scene name='pdbligand=RXV:6-METHOXY-4-(2-{4-[([1,3]OXATHIOLO[5,4-C]PYRIDIN-6-YLMETHYL)AMINO]PIPERIDIN-1-YL}ETHYL)QUINOLINE-3-CARBONITRILE'>RXV</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xcr OCA], [https://pdbe.org/2xcr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xcr RCSB], [https://www.ebi.ac.uk/pdbsum/2xcr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xcr ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | == Function == |
| - | <table> | + | [https://www.uniprot.org/uniprot/GYRA_STAAN GYRA_STAAN] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01897][https://www.uniprot.org/uniprot/GYRB_STAAN GYRB_STAAN] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xc/2xcr_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xc/2xcr_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xcr ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2xcr" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Gyrase|Gyrase]] | + | *[[Gyrase 3D Structures|Gyrase 3D Structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
| - | [[Category: Bax | + | [[Category: Synthetic construct]] |
| - | [[Category: Brown | + | [[Category: Bax BD]] |
| - | [[Category: Chan | + | [[Category: Brown KK]] |
| - | [[Category: Eggleston | + | [[Category: Chan PF]] |
| - | [[Category: Fosberry | + | [[Category: Eggleston DS]] |
| - | [[Category: Gentry | + | [[Category: Fosberry A]] |
| - | [[Category: Giordano | + | [[Category: Gentry DR]] |
| - | [[Category: Gorrec | + | [[Category: Giordano I]] |
| - | [[Category: Gwynn | + | [[Category: Gorrec F]] |
| - | [[Category: Hann | + | [[Category: Gwynn MN]] |
| - | [[Category: Hennessy | + | [[Category: Hann MM]] |
| - | [[Category: Hibbs | + | [[Category: Hennessy A]] |
| - | [[Category: Huang | + | [[Category: Hibbs M]] |
| - | [[Category: Jones | + | [[Category: Huang J]] |
| - | [[Category: Jones | + | [[Category: Jones E]] |
| - | [[Category: Lewis | + | [[Category: Jones J]] |
| - | [[Category: May | + | [[Category: Lewis CJ]] |
| - | [[Category: Pearson | + | [[Category: May EW]] |
| - | [[Category: Shen | + | [[Category: Pearson ND]] |
| - | [[Category: Shillings | + | [[Category: Shen C]] |
| - | [[Category: Singh | + | [[Category: Shillings A]] |
| - | [[Category: Spitzfaden | + | [[Category: Singh O]] |
| - | [[Category: Theobald | + | [[Category: Spitzfaden C]] |
| - | [[Category: Wohlkonig | + | [[Category: Theobald AF]] |
| - | + | [[Category: Wohlkonig A]] | |
Current revision
The 3.5A crystal structure of the catalytic core (B'A' region) of Staphylococcus aureus DNA Gyrase complexed with GSK299423 and DNA
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Categories: Large Structures | Staphylococcus aureus | Synthetic construct | Bax BD | Brown KK | Chan PF | Eggleston DS | Fosberry A | Gentry DR | Giordano I | Gorrec F | Gwynn MN | Hann MM | Hennessy A | Hibbs M | Huang J | Jones E | Jones J | Lewis CJ | May EW | Pearson ND | Shen C | Shillings A | Singh O | Spitzfaden C | Theobald AF | Wohlkonig A
