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2wry

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==CRYSTAL STRUCTURE OF CHICKEN CYTOKINE INTERLEUKIN 1 BETA==
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<StructureSection load='2wry' size='340' side='right' caption='[[2wry]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
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==Crystal structure of chicken cytokine interleukin 1 beta==
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<StructureSection load='2wry' size='340' side='right'caption='[[2wry]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wry]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WRY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wry]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WRY FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wry OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wry RCSB], [http://www.ebi.ac.uk/pdbsum/2wry PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wry OCA], [https://pdbe.org/2wry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wry RCSB], [https://www.ebi.ac.uk/pdbsum/2wry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wry ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O73909_CHICK O73909_CHICK] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).[RuleBase:RU003753]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/2wry_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/2wry_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wry ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2wry" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Interleukin|Interleukin]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Cheng, C S.]]
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[[Category: Large Structures]]
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[[Category: Lee, L H.]]
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[[Category: Cheng CS]]
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[[Category: Lu, W S.]]
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[[Category: Lee LH]]
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[[Category: Lyu, P C.]]
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[[Category: Lu WS]]
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[[Category: Wang, W C.]]
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[[Category: Lyu PC]]
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[[Category: Yin, H S.]]
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[[Category: Wang WC]]
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[[Category: Immune system]]
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[[Category: Yin HS]]
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[[Category: Inflammatory response]]
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[[Category: Mitogen]]
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[[Category: Pyrogen]]
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Current revision

Crystal structure of chicken cytokine interleukin 1 beta

PDB ID 2wry

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