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==Inhibición de la Telomerasa y otros Temas Relacionados== | ==Inhibición de la Telomerasa y otros Temas Relacionados== | ||
| - | <StructureSection load='1nzm' size='340' side='right' caption='Caption for this structure' scene=''> | + | <StructureSection load='1nzm' size='340' side='right' caption='Caption for this structure' scene='60/601870/Rmn_phenquadruplex/2'> |
In progress... | In progress... | ||
Soy novata, así que no me responsabilizo del resultado. | Soy novata, así que no me responsabilizo del resultado. | ||
I am a rooky user, sorry. No liability on the displayed contents... | I am a rooky user, sorry. No liability on the displayed contents... | ||
| + | La imagen inicial de esta página representa a un ligando de fenantrolina unido a un ADN cuádruple-G derivado del promotor c-myc. | ||
| + | <ref>pmid 24356977</ref> | ||
== Function == | == Function == | ||
Enlazamos a una estructura de Proteopedia, a la transcriptasa hTERT [[3du5]] | Enlazamos a una estructura de Proteopedia, a la transcriptasa hTERT [[3du5]] | ||
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Un ejemplo de un ligando interaccionado con ADN cuádruple. | Un ejemplo de un ligando interaccionado con ADN cuádruple. | ||
<scene name='60/601870/Quadruplex/1'>Quadruplex Ligand</scene> | <scene name='60/601870/Quadruplex/1'>Quadruplex Ligand</scene> | ||
| + | |||
| + | Otro ejemplo muy interesante.<ref>pmid | ||
| + | 23514618</ref><scene name='60/601870/Ligando_steve/1'>Complejo ADN-ligando</scene> | ||
Estudio de resonancia magnética nuclear con la interacción ADN-ligando. | Estudio de resonancia magnética nuclear con la interacción ADN-ligando. | ||
<scene name='60/601870/Rmn_ligando_quadruplex/2'>Estructura de RMN</scene> | <scene name='60/601870/Rmn_ligando_quadruplex/2'>Estructura de RMN</scene> | ||
| + | <ref>pmid 17385760</ref> | ||
== Disease == | == Disease == | ||
| - | + | Relevancia por sus múltiples aplicaciones dentro de la quimioterapia del cáncer. | |
== Relevance == | == Relevance == | ||
| - | + | Existen pocas estructuras resueltas de este tipo. | |
== Structural highlights == | == Structural highlights == | ||
| - | + | El ADN adopta una estructura secundaria de cuádruple-G. Esta estrucutura es muy sensible a las condiciones iónicas: el plegamiento difiere en función de la presencia de iones sodio o potasio. | |
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
| - | + | <references/> | |
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
| - | <references/> | ||
| - | <ref>17385760</ref> | ||
Current revision
Inhibición de la Telomerasa y otros Temas Relacionados
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