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1iva

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[[Image:1iva.gif|left|200px]]
 
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{{Structure
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==STRUCTURE-ACTIVITY RELATIONSHIPS FOR P-TYPE CALCIUM CHANNEL SELECTIVE OMEGA-AGATOXINS==
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|PDB= 1iva |SIZE=350|CAPTION= <scene name='initialview01'>1iva</scene>
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<StructureSection load='1iva' size='340' side='right'caption='[[1iva]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1iva]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Agelenopsis_aperta Agelenopsis aperta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IVA FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iva OCA], [https://pdbe.org/1iva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iva RCSB], [https://www.ebi.ac.uk/pdbsum/1iva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iva ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''STRUCTURE-ACTIVITY RELATIONSHIPS FOR P-TYPE CALCIUM CHANNEL SELECTIVE OMEGA-AGATOXINS'''
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[https://www.uniprot.org/uniprot/TX23A_AGEAP TX23A_AGEAP] Omega-agatoxins inhibit neuronal voltage-gated calcium channels. This toxin acts by modifying the gating of the high voltage activated P-type Cav2.1/CACNA1A channel. Is a potent blocker in both insect and mammalian central neurons.<ref>PMID:11055992</ref> <ref>PMID:11522785</ref> <ref>PMID:1311418</ref> <ref>PMID:7898748</ref> <ref>PMID:8250902</ref> <ref>PMID:9120560</ref> <ref>PMID:9129813</ref>
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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1IVA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Agelenopsis_aperta Agelenopsis aperta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IVA OCA].
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</StructureSection>
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==Reference==
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Structure-activity relationships for P-type calcium channel-selective omega-agatoxins., Reily MD, Holub KE, Gray WR, Norris TM, Adams ME, Nat Struct Biol. 1994 Dec;1(12):853-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7773772 7773772]
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[[Category: Agelenopsis aperta]]
[[Category: Agelenopsis aperta]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Holub, K E.]]
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[[Category: Holub KE]]
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[[Category: Reily, M D.]]
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[[Category: Reily MD]]
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[[Category: neurotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:55:23 2008''
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Current revision

STRUCTURE-ACTIVITY RELATIONSHIPS FOR P-TYPE CALCIUM CHANNEL SELECTIVE OMEGA-AGATOXINS

PDB ID 1iva

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