2vrh

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==Structure of the E. coli trigger factor bound to a translating ribosome==
==Structure of the E. coli trigger factor bound to a translating ribosome==
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<StructureSection load='2vrh' size='340' side='right' caption='[[2vrh]], [[Resolution|resolution]] 19.00&Aring;' scene=''>
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<SX load='2vrh' size='340' side='right' viewer='molstar' caption='[[2vrh]], [[Resolution|resolution]] 19.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vrh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VRH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vrh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VRH FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 19&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1p9y|1p9y]], [[2j28|2j28]], [[2vhm|2vhm]], [[2wwq|2wwq]], [[1p86|1p86]], [[2aw4|2aw4]], [[1w26|1w26]], [[1w2b|1w2b]], [[1p85|1p85]], [[2vhn|2vhn]], [[1oms|1oms]], [[2awb|2awb]], [[1l1p|1l1p]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vrh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vrh RCSB], [http://www.ebi.ac.uk/pdbsum/2vrh PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vrh OCA], [https://pdbe.org/2vrh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vrh RCSB], [https://www.ebi.ac.uk/pdbsum/2vrh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vrh ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TIG_ECOLI TIG_ECOLI] Involved in protein export. Acts as a chaperone by maintaining the newly synthesized secretory and non-secretory proteins in an open conformation. Binds to nascent polypeptide chains via ribosomal protein L23 (PubMed:12226666). Functions as a peptidyl-prolyl cis-trans isomerase in vitro, this activity is dispensible in vivo for chaperone activity.<ref>PMID:8633085</ref> <ref>PMID:8521806</ref> <ref>PMID:14726952</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/2vrh_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/2vrh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vrh ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2vrh" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Ribosomal protein L23|Ribosomal protein L23]]
*[[Ribosomal protein L24|Ribosomal protein L24]]
*[[Ribosomal protein L24|Ribosomal protein L24]]
*[[Ribosomal protein L29|Ribosomal protein L29]]
*[[Ribosomal protein L29|Ribosomal protein L29]]
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<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Ban, N.]]
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[[Category: Large Structures]]
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[[Category: Boehringer, D.]]
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[[Category: Ban N]]
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[[Category: Bukau, B.]]
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[[Category: Boehringer D]]
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[[Category: Deuerling, E.]]
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[[Category: Bukau B]]
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[[Category: Hoffmann, A.]]
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[[Category: Deuerling E]]
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[[Category: Lozza, J.]]
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[[Category: Hoffmann A]]
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[[Category: Maier, T.]]
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[[Category: Lozza J]]
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[[Category: Merz, F.]]
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[[Category: Maier T]]
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[[Category: Preissler, S.]]
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[[Category: Merz F]]
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[[Category: Rutkowska, A.]]
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[[Category: Preissler S]]
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[[Category: Schaffitzel, C.]]
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[[Category: Rutkowska A]]
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[[Category: Cell cycle]]
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[[Category: Schaffitzel C]]
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[[Category: Cell division]]
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[[Category: Chaperone]]
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[[Category: Co-translational protein folding]]
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[[Category: Isomerase]]
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[[Category: Ribonucleoprotein]]
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[[Category: Ribosomal protein]]
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[[Category: Ribosome]]
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[[Category: Ribosome-nascent chain complex]]
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[[Category: Rna-binding]]
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[[Category: Rotamase]]
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[[Category: Rrna-binding]]
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[[Category: Trigger factor]]
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Current revision

Structure of the E. coli trigger factor bound to a translating ribosome

2vrh, resolution 19.00Å

Proteopedia Page Contributors and Editors (what is this?)

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