2x35

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==MOLECULAR BASIS OF HISTONE H3K36ME3 RECOGNITION BY THE PWWP DOMAIN OF BRPF1.==
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<StructureSection load='2x35' size='340' side='right' caption='[[2x35]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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==Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.==
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<StructureSection load='2x35' size='340' side='right'caption='[[2x35]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2x35]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X35 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X35 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2x35]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X35 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2d9e|2d9e]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x35 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x35 RCSB], [http://www.ebi.ac.uk/pdbsum/2x35 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x35 OCA], [https://pdbe.org/2x35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x35 RCSB], [https://www.ebi.ac.uk/pdbsum/2x35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x35 ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x3/2x35_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x3/2x35_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x35 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2x35" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Peregrin|Peregrin]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Allen, M D.]]
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[[Category: Large Structures]]
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[[Category: Bonadies, N.]]
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[[Category: Allen MD]]
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[[Category: Bycroft, M.]]
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[[Category: Bonadies N]]
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[[Category: Freund, S M.V.]]
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[[Category: Bycroft M]]
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[[Category: Gottgens, B.]]
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[[Category: Freund SMV]]
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[[Category: Huntly, B J.P.]]
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[[Category: Gottgens B]]
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[[Category: Kvinlaug, B.]]
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[[Category: Huntly BJP]]
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[[Category: Santiveri, C M.]]
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[[Category: Kvinlaug B]]
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[[Category: Vezzoli, A.]]
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[[Category: Santiveri CM]]
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[[Category: Chromatin regulator]]
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[[Category: Vezzoli A]]
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[[Category: Dna-binding]]
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[[Category: Metal-binding]]
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[[Category: Nucleosome]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc-finger]]
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Current revision

Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.

PDB ID 2x35

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