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2d07
From Proteopedia
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==Crystal Structure of SUMO-3-modified Thymine-DNA Glycosylase== | ==Crystal Structure of SUMO-3-modified Thymine-DNA Glycosylase== | ||
| - | <StructureSection load='2d07' size='340' side='right' caption='[[2d07]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='2d07' size='340' side='right'caption='[[2d07]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2d07]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2d07]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D07 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <table> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d07 OCA], [https://pdbe.org/2d07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d07 RCSB], [https://www.ebi.ac.uk/pdbsum/2d07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d07 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TDG_HUMAN TDG_HUMAN] In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d0/2d07_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d0/2d07_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d07 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2d07" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[DNA glycosylase|DNA glycosylase]] | + | *[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]] |
| - | *[[SUMO|SUMO]] | + | *[[SUMO 3D Structures|SUMO 3D Structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Baba | + | [[Category: Large Structures]] |
| - | [[Category: Hanaoka | + | [[Category: Baba D]] |
| - | [[Category: Hiroaki | + | [[Category: Hanaoka F]] |
| - | [[Category: Jee | + | [[Category: Hiroaki H]] |
| - | [[Category: Maita | + | [[Category: Jee JG]] |
| - | [[Category: Saitoh | + | [[Category: Maita N]] |
| - | [[Category: Shirakawa | + | [[Category: Saitoh H]] |
| - | [[Category: Sugasawa | + | [[Category: Shirakawa M]] |
| - | [[Category: Tochio | + | [[Category: Sugasawa K]] |
| - | [[Category: Uchimura | + | [[Category: Tochio H]] |
| - | + | [[Category: Uchimura Y]] | |
Current revision
Crystal Structure of SUMO-3-modified Thymine-DNA Glycosylase
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Categories: Homo sapiens | Large Structures | Baba D | Hanaoka F | Hiroaki H | Jee JG | Maita N | Saitoh H | Shirakawa M | Sugasawa K | Tochio H | Uchimura Y
