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2fwl
From Proteopedia
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==The cytochrome c552/CuA complex from Thermus thermophilus== | ==The cytochrome c552/CuA complex from Thermus thermophilus== | ||
| - | <StructureSection load='2fwl' size='340' side='right' caption='[[2fwl]], [[NMR_Ensembles_of_Models | 3 NMR models]]' scene=''> | + | <StructureSection load='2fwl' size='340' side='right'caption='[[2fwl]], [[NMR_Ensembles_of_Models | 3 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2fwl]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2fwl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thet8 Thet8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FWL FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CUA:DINUCLEAR+COPPER+ION'>CUA</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CUA:DINUCLEAR+COPPER+ION'>CUA</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ehk|1ehk]], [[1dt1|1dt1]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ehk|1ehk]], [[1dt1|1dt1]]</div></td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cytochrome-c_oxidase Cytochrome-c oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.9.3.1 1.9.3.1] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fwl OCA], [https://pdbe.org/2fwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fwl RCSB], [https://www.ebi.ac.uk/pdbsum/2fwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fwl ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/CY552_THETH CY552_THETH]] This monoheme basic protein appears to function as an electron donor to cytochrome oxidase in T.thermophilus. [[https://www.uniprot.org/uniprot/COX2_THETH COX2_THETH]] Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/2fwl_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/2fwl_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fwl ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2fwl" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Cytochrome c | + | *[[Cytochrome c nitrite reductase|Cytochrome c nitrite reductase]] |
| - | *[[ | + | *[[Cytochrome c oxidase 3D structures|Cytochrome c oxidase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Cytochrome-c oxidase]] | [[Category: Cytochrome-c oxidase]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Loehr, F | + | [[Category: Thet8]] |
| - | [[Category: Ludwig, B | + | [[Category: Loehr, F]] |
| - | [[Category: Luecke, C | + | [[Category: Ludwig, B]] |
| - | [[Category: Maneg, O | + | [[Category: Luecke, C]] |
| - | [[Category: Mukrasch, M D | + | [[Category: Maneg, O]] |
| - | [[Category: Muresanu, L | + | [[Category: Mukrasch, M D]] |
| - | [[Category: Pristovsek, P | + | [[Category: Muresanu, L]] |
| - | [[Category: Rueterjans, H | + | [[Category: Pristovsek, P]] |
| + | [[Category: Rueterjans, H]] | ||
[[Category: Docking calculation]] | [[Category: Docking calculation]] | ||
[[Category: Electron transfer pathway]] | [[Category: Electron transfer pathway]] | ||
[[Category: Electron transport-oxidoreductase complex]] | [[Category: Electron transport-oxidoreductase complex]] | ||
[[Category: Redox protein complex]] | [[Category: Redox protein complex]] | ||
Current revision
The cytochrome c552/CuA complex from Thermus thermophilus
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