4l5y

<StructureSection load='4l5y' size='340' side='right'caption='[[4l5y]], [[Resolution|resolution]] 2.10&Aring;' scene=''>

<table><tr><td colspan='2'>[[4l5y]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L5Y FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.0957&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5y OCA], [https://pdbe.org/4l5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l5y RCSB], [https://www.ebi.ac.uk/pdbsum/4l5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l5y ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/I0B503_SCHMA I0B503_SCHMA] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates (By similarity).[HAMAP-Rule:MF_03155]

*[[5'-deoxy-5'-methylthioadenosine phosphorylase 3D structures|5'-deoxy-5'-methylthioadenosine phosphorylase 3D structures]]

[[Category: Large Structures]]

[[Category: Schistosoma mansoni]]

[[Category: Brandao-Neto J]]

[[Category: DeMarco R]]

[[Category: Pereira HM]]

[[Category: Torini JR]]