4nej
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Small molecular fragment bound to crystal contact interface of Interleukin-2== | |
| + | <StructureSection load='4nej' size='340' side='right'caption='[[4nej]], [[Resolution|resolution]] 1.92Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4nej]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NEJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.919Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2K1:5-METHYLFURAN-2-CARBOXYLIC+ACID'>2K1</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nej OCA], [https://pdbe.org/4nej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nej RCSB], [https://www.ebi.ac.uk/pdbsum/4nej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nej ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. | ||
| - | + | ==See Also== | |
| - | + | *[[Interleukin 3D structures|Interleukin 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Allen KN]] | ||
| + | [[Category: Brenke R]] | ||
| + | [[Category: Jehle S]] | ||
| + | [[Category: Kozakov D]] | ||
| + | [[Category: Vajda S]] | ||
Current revision
Small molecular fragment bound to crystal contact interface of Interleukin-2
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Categories: Homo sapiens | Large Structures | Allen KN | Brenke R | Jehle S | Kozakov D | Vajda S
