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4pkx
From Proteopedia
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==The structure of a conserved Piezo channel domain reveals a novel beta sandwich fold== | ==The structure of a conserved Piezo channel domain reveals a novel beta sandwich fold== | ||
| - | <StructureSection load='4pkx' size='340' side='right' caption='[[4pkx]], [[Resolution|resolution]] 2.54Å' scene=''> | + | <StructureSection load='4pkx' size='340' side='right'caption='[[4pkx]], [[Resolution|resolution]] 2.54Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4pkx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PKX OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4pkx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PKX FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pkx OCA], [https://pdbe.org/4pkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pkx RCSB], [https://www.ebi.ac.uk/pdbsum/4pkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pkx ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PIEZ1_CAEEL PIEZ1_CAEEL] Pore-forming subunit of a mechanosensitive non-specific cation channel (By similarity). Generates currents characterized by a linear current-voltage relationship (By similarity). Plays a role in reproduction by positively regulating inter-tissue signaling to promote oocyte maturation, ovulation and fertilization, and sperm navigation from and to the spermatheca (PubMed:32490809). May play a role in regulating cytosolic and endoplasmic reticulum calcium ion release (PubMed:32490809).[UniProtKB:Q92508]<ref>PMID:32490809</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4pkx" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Caenorhabditis elegans]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Kaiser J]] |
| - | [[Category: | + | [[Category: Kamajaya A]] |
| - | [[Category: | + | [[Category: Lee J]] |
| - | [[Category: | + | [[Category: Rees DC]] |
| - | [[Category: | + | [[Category: Reid M]] |
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Current revision
The structure of a conserved Piezo channel domain reveals a novel beta sandwich fold
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