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1yq8

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==PRD1 vertex protein P5==
==PRD1 vertex protein P5==
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<StructureSection load='1yq8' size='340' side='right' caption='[[1yq8]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='1yq8' size='340' side='right'caption='[[1yq8]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1yq8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_prd1 Enterobacteria phage prd1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YQ8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1yq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterobacteria_phage_PRD1 Enterobacteria phage PRD1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YQ8 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yq5|1yq5]], [[1yq6|1yq6]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yq8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yq8 RCSB], [http://www.ebi.ac.uk/pdbsum/1yq8 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yq8 OCA], [https://pdbe.org/1yq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1yq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yq8 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/P5_BPPRD P5_BPPRD] In association with P31 and P2, forms the spike complexes located at the 5-fold vertices of the capsid. Essential for viral infectivity.<ref>PMID:10956048</ref>
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Comparisons of bacteriophage PRD1 and adenovirus protein structures and virion architectures have been instrumental in unraveling an evolutionary relationship and have led to a proposal of a phylogeny-based virus classification. The structure of the PRD1 spike protein P5 provides further insight into the evolution of viral proteins. The crystallized P5 fragment comprises two structural domains: a globular knob and a fibrous shaft. The head folds into a ten-stranded jelly roll beta barrel, which is structurally related to the tumor necrosis factor (TNF) and the PRD1 coat protein domains. The shaft domain is a structural counterpart to the adenovirus spike shaft. The structural relationships between PRD1, TNF, and adenovirus proteins suggest that the vertex proteins may have originated from an ancestral TNF-like jelly roll coat protein via a combination of gene duplication and deletion.
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The structure of the bacteriophage PRD1 spike sheds light on the evolution of viral capsid architecture.,Merckel MC, Huiskonen JT, Bamford DH, Goldman A, Tuma R Mol Cell. 2005 Apr 15;18(2):161-70. PMID:15837420<ref>PMID:15837420</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Enterobacteria phage prd1]]
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[[Category: Enterobacteria phage PRD1]]
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[[Category: Bamford, D H.]]
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[[Category: Large Structures]]
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[[Category: Goldman, A.]]
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[[Category: Bamford DH]]
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[[Category: Huiskonen, J T.]]
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[[Category: Goldman A]]
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[[Category: Merckel, M C.]]
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[[Category: Huiskonen JT]]
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[[Category: Tuma, R.]]
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[[Category: Merckel MC]]
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[[Category: Beta-spiral beta-jelly-roll]]
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[[Category: Tuma R]]
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[[Category: Viral protein]]
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Current revision

PRD1 vertex protein P5

PDB ID 1yq8

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