2kq0

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==Human NEDD4 3rd WW Domain Complex with Ebola Zaire Virus Matrix Protein VP40 Derived Peptide ILPTAPPEYMEA==
==Human NEDD4 3rd WW Domain Complex with Ebola Zaire Virus Matrix Protein VP40 Derived Peptide ILPTAPPEYMEA==
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<StructureSection load='2kq0' size='340' side='right' caption='[[2kq0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2kq0' size='340' side='right'caption='[[2kq0]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2kq0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KQ0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2kq0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/HTLV-1_isolate_Mel_15 HTLV-1 isolate Mel 15] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KQ0 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kpz|2kpz]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NEDD4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kq0 OCA], [https://pdbe.org/2kq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kq0 RCSB], [https://www.ebi.ac.uk/pdbsum/2kq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kq0 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kq0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kq0 RCSB], [http://www.ebi.ac.uk/pdbsum/2kq0 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NEDD4_HUMAN NEDD4_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2.<ref>PMID:17218260</ref> <ref>PMID:18562292</ref> <ref>PMID:20086093</ref> <ref>PMID:21765395</ref> <ref>PMID:21399620</ref>
==See Also==
==See Also==
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*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: HTLV-1 isolate Mel 15]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blanco, F J.]]
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[[Category: Large Structures]]
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[[Category: Bonet, R.]]
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[[Category: Blanco FJ]]
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[[Category: Cobos, E S.]]
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[[Category: Bonet R]]
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[[Category: Iglesias-Bexiga, M.]]
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[[Category: Cobos ES]]
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[[Category: Luque, I.]]
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[[Category: Iglesias-Bexiga M]]
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[[Category: Macias, M.]]
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[[Category: Luque I]]
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[[Category: Cell membrane]]
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[[Category: Macias M]]
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[[Category: Complex]]
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[[Category: Ebola]]
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[[Category: Host-virus interaction]]
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[[Category: Ligase]]
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[[Category: Nedd4]]
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[[Category: Phosphoprotein]]
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[[Category: Ribonucleoprotein]]
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[[Category: Rna replication]]
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[[Category: Rna-binding]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Viral matrix protein]]
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[[Category: Virion]]
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[[Category: Virus l domain]]
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[[Category: Ww domain]]
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Current revision

Human NEDD4 3rd WW Domain Complex with Ebola Zaire Virus Matrix Protein VP40 Derived Peptide ILPTAPPEYMEA

PDB ID 2kq0

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