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4d01

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==Crystal Structure of the Extracellular Domain of the Human Alpha9 Nicotinic Acetylcholine Receptor==
==Crystal Structure of the Extracellular Domain of the Human Alpha9 Nicotinic Acetylcholine Receptor==
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<StructureSection load='4d01' size='340' side='right' caption='[[4d01]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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<StructureSection load='4d01' size='340' side='right'caption='[[4d01]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4d01]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D01 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D01 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4d01]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D01 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.795&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uxu|4uxu]], [[4uy2|4uy2]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d01 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d01 RCSB], [http://www.ebi.ac.uk/pdbsum/4d01 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d01 OCA], [https://pdbe.org/4d01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d01 RCSB], [https://www.ebi.ac.uk/pdbsum/4d01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d01 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACHA9_HUMAN ACHA9_HUMAN] Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion.<ref>PMID:11752216</ref> <ref>PMID:11021840</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4d01" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Acetyl choline receptor 3D structures|Acetyl choline receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Giastas, P.]]
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[[Category: Homo sapiens]]
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[[Category: Tzartos, S J.]]
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[[Category: Large Structures]]
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[[Category: Zarkadas, E.]]
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[[Category: Giastas P]]
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[[Category: Zouridakis, M.]]
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[[Category: Tzartos SJ]]
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[[Category: Cys-loop receptor]]
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[[Category: Zarkadas E]]
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[[Category: Ligand binding domain]]
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[[Category: Zouridakis M]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of the Extracellular Domain of the Human Alpha9 Nicotinic Acetylcholine Receptor

PDB ID 4d01

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