3j8c
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3j8c is ON HOLD Authors: Erzberger, J.P., Ban, N. Description: Model of the human eIF3 PCI-MPN octamer docked into the 43S EM map) |
|||
| (9 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Model of the human eIF3 PCI-MPN octamer docked into the 43S EM map== | |
| + | <SX load='3j8c' size='340' side='right' viewer='molstar' caption='[[3j8c]], [[Resolution|resolution]] 11.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3j8c]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3j7k 3j7k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J8C FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 11.6Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j8c OCA], [https://pdbe.org/3j8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j8c RCSB], [https://www.ebi.ac.uk/pdbsum/3j8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j8c ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/EIF3A_HUMAN EIF3A_HUMAN] RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815).[HAMAP-Rule:MF_03000]<ref>PMID:11169732</ref> <ref>PMID:17581632</ref> <ref>PMID:25849773</ref> <ref>PMID:27462815</ref> (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634).<ref>PMID:23766293</ref> <ref>PMID:24357634</ref> (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).<ref>PMID:18056426</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ban N]] | ||
| + | [[Category: Erzberger JP]] | ||
Current revision
Model of the human eIF3 PCI-MPN octamer docked into the 43S EM map
| |||||||||
