4rie
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Landomycin Glycosyltransferase LanGT2== | |
| + | <StructureSection load='4rie' size='340' side='right'caption='[[4rie]], [[Resolution|resolution]] 2.16Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4rie]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cyanogenus Streptomyces cyanogenus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RIE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.162Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rie OCA], [https://pdbe.org/4rie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rie RCSB], [https://www.ebi.ac.uk/pdbsum/4rie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rie ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q9ZGC0_STRCY Q9ZGC0_STRCY] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The structures of the O-glycosyltransferase LanGT2 and the engineered, CC bond-forming variant LanGT2S8Ac show how the replacement of a single loop can change the functionality of the enzyme. Crystal structures of the enzymes in complex with a nonhydrolyzable nucleotide-sugar analogue revealed that there is a conformational transition to create the binding sites for the aglycon substrate. This induced-fit transition was explored by molecular docking experiments with various aglycon substrates. | ||
| - | + | Structural Characterization of O- and C-Glycosylating Variants of the Landomycin Glycosyltransferase LanGT2.,Tam HK, Harle J, Gerhardt S, Rohr J, Wang G, Thorson JS, Bigot A, Lutterbeck M, Seiche W, Breit B, Bechthold A, Einsle O Angew Chem Int Ed Engl. 2015 Jan 7. doi: 10.1002/anie.201409792. PMID:25581707<ref>PMID:25581707</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4rie" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Streptomyces cyanogenus]] | ||
| + | [[Category: Bechthold A]] | ||
| + | [[Category: Breit B]] | ||
| + | [[Category: Einsle O]] | ||
| + | [[Category: Gerhardt S]] | ||
| + | [[Category: Tam HK]] | ||
Current revision
Landomycin Glycosyltransferase LanGT2
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