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| - | [[Image:1jsk.gif|left|200px]] | + | #REDIRECT [[4pp8]] This PDB entry is obsolete and replaced by 4pp8 |
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| - | {{Structure
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| - | |PDB= 1jsk |SIZE=350|CAPTION= <scene name='initialview01'>1jsk</scene>, resolution 3.50Å
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| - | |SITE=
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| - | |LIGAND=
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| - | |ACTIVITY=
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| - | |GENE= NKG2D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), RAE-1 Beta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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| - | }}
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| - | '''CRYSTAL STRUCTURE OF MURINE NK CELL LIGAND RAE-1 BETA IN COMPLEX WITH NKG2D'''
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| - | ==Overview==
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| - | Induced by retinoic acid and implicated in playing a role in development, rodent RAE-1 proteins are ligands for the activating immunoreceptor NKG2D, widely expressed on natural killer cells, T cells, and macrophages. RAE-1 proteins (alpha, beta, gamma, and delta) are distant major histocompatibility complex (MHC) class I homologs, comprising isolated alpha1alpha2 platform domains. The crystal structure of RAE-1beta was distorted from other MHC homologs and displayed noncanonical disulfide bonds. The loss of any remnant of a peptide binding groove was facilitated by the close approach of the groove-defining helices through a hydrophobic, leucine-rich interface. The RAE-1beta-murine NKG2D complex structure resembled the human NKG2D-MICA receptor-ligand complex and further demonstrated the promiscuity of the NKG2D ligand binding site.
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| - | ==About this Structure==
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| - | 1JSK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSK OCA].
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| - | ==Reference==
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| - | Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D., Li P, McDermott G, Strong RK, Immunity. 2002 Jan;16(1):77-86. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11825567 11825567]
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| - | [[Category: Mus musculus]]
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| - | [[Category: Protein complex]]
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| - | [[Category: Li, P.]]
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| - | [[Category: Strong, R K.]]
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| - | [[Category: immune system]]
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| - | [[Category: mhc-i platform]]
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| - | [[Category: murine nk cell ligand]]
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| - | [[Category: nkg2d]]
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| - | [[Category: rae-1 beta]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:07:51 2008''
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