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4avt

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==Structure of CPHPC bound to Serum Amyloid P Component==
==Structure of CPHPC bound to Serum Amyloid P Component==
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<StructureSection load='4avt' size='340' side='right' caption='[[4avt]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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<StructureSection load='4avt' size='340' side='right'caption='[[4avt]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4avt]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AVT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4avt]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AVT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GHE:(2R)-1-[6-[(2R)-2-CARBOXYPYRROLIDIN-1-YL]-6-OXIDANYLIDENE-HEXANOYL]PYRROLIDINE-2-CARBOXYLIC+ACID'>GHE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gyk|1gyk]], [[1lgn|1lgn]], [[1sac|1sac]], [[2a3w|2a3w]], [[2a3x|2a3x]], [[2a3y|2a3y]], [[2w08|2w08]], [[4avs|4avs]], [[4avv|4avv]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GHE:(2R)-1-[6-[(2R)-2-CARBOXYPYRROLIDIN-1-YL]-6-OXIDANYLIDENE-HEXANOYL]PYRROLIDINE-2-CARBOXYLIC+ACID'>GHE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4avt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4avt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4avt RCSB], [http://www.ebi.ac.uk/pdbsum/4avt PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4avt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4avt OCA], [https://pdbe.org/4avt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4avt RCSB], [https://www.ebi.ac.uk/pdbsum/4avt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4avt ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/SAMP_HUMAN SAMP_HUMAN]] Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
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[https://www.uniprot.org/uniprot/SAMP_HUMAN SAMP_HUMAN] Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SAMP_HUMAN SAMP_HUMAN]] Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
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[https://www.uniprot.org/uniprot/SAMP_HUMAN SAMP_HUMAN] Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4avt" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Serum amyloid P-component|Serum amyloid P-component]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kolstoe, S E.]]
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[[Category: Large Structures]]
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[[Category: Purvis, A.]]
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[[Category: Kolstoe SE]]
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[[Category: Wood, S P.]]
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[[Category: Purvis A]]
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[[Category: Lectin]]
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[[Category: Wood SP]]
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[[Category: Metal-binding]]
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[[Category: Sugar binding protein]]
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Current revision

Structure of CPHPC bound to Serum Amyloid P Component

PDB ID 4avt

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