4rk8

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(New page: '''Unreleased structure''' The entry 4rk8 is ON HOLD until Paper Publication Authors: Zhu, L., Ren, X., Zhu, J., Li, H. Description: Crystal structure of human dihydroorotate dehydroge...)
Current revision (17:51, 20 September 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4rk8 is ON HOLD until Paper Publication
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==Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356==
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<StructureSection load='4rk8' size='340' side='right'caption='[[4rk8]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4rk8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RK8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3RV:5-FLUORO-2-{[(5Z)-5-(NAPHTHALEN-1-YLMETHYLIDENE)-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL]AMINO}BENZOIC+ACID'>3RV</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rk8 OCA], [https://pdbe.org/4rk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rk8 RCSB], [https://www.ebi.ac.uk/pdbsum/4rk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rk8 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
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Authors: Zhu, L., Ren, X., Zhu, J., Li, H.
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==See Also==
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*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
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Description: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Li H]]
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[[Category: Ren X]]
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[[Category: Zhu J]]
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[[Category: Zhu L]]

Current revision

Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356

PDB ID 4rk8

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