4rl0
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4rl0 is ON HOLD Authors: Feng, H., Ding, J., Zhu, D., Liu, X., Xu, X., Zhang, Y., Zang, S., Wang, D.-C., Liu, W. Description: Structural and mechan...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins== | |
| + | <StructureSection load='4rl0' size='340' side='right'caption='[[4rl0]], [[Resolution|resolution]] 1.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4rl0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RL0 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3S0:(2R,5S)-5-[(CARBAMOYLOXY)METHYL]-2-[(R)-CARBOXY{[(2Z)-2-(FURAN-2-YL)-2-(METHOXYIMINO)ACETYL]AMINO}METHYL]-5,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC+ACID'>3S0</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rl0 OCA], [https://pdbe.org/4rl0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rl0 RCSB], [https://www.ebi.ac.uk/pdbsum/4rl0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rl0 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. | ||
| - | + | ==See Also== | |
| - | + | *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Klebsiella pneumoniae]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ding J]] | ||
| + | [[Category: Feng H]] | ||
| + | [[Category: Liu W]] | ||
| + | [[Category: Liu X]] | ||
| + | [[Category: Wang D-C]] | ||
| + | [[Category: Xu X]] | ||
| + | [[Category: Zang S]] | ||
| + | [[Category: Zhang Y]] | ||
| + | [[Category: Zhu D]] | ||
Current revision
Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins
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Categories: Klebsiella pneumoniae | Large Structures | Ding J | Feng H | Liu W | Liu X | Wang D-C | Xu X | Zang S | Zhang Y | Zhu D
