4qa8

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==Crystal structure of LprF from Mycobacterium bovis==
==Crystal structure of LprF from Mycobacterium bovis==
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<StructureSection load='4qa8' size='340' side='right' caption='[[4qa8]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
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<StructureSection load='4qa8' size='340' side='right'caption='[[4qa8]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qa8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QA8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qa8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_variant_bovis_AF2122/97 Mycobacterium tuberculosis variant bovis AF2122/97]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QA8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PJZ:(2R)-2-(DODECANOYLOXY)PROPYL+(4E,6E,8E,10E,12E)-PENTADECA-4,6,8,10,12-PENTAENOATE'>PJZ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qa8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qa8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qa8 RCSB], [http://www.ebi.ac.uk/pdbsum/4qa8 PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PJZ:(2R)-2-(DODECANOYLOXY)PROPYL+(4E,6E,8E,10E,12E)-PENTADECA-4,6,8,10,12-PENTAENOATE'>PJZ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qa8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qa8 OCA], [https://pdbe.org/4qa8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qa8 RCSB], [https://www.ebi.ac.uk/pdbsum/4qa8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qa8 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/LPRF_MYCBO LPRF_MYCBO]
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The Gram-positive bacteria Mycobacterium tuberculosis and M. bovis are causative agents of tuberculosis in humans and cattle. The lipoprotein LprF is found in M. tuberculosis and M. bovis but not in the nonpathogenic M. smegmatis. To date, the role of LprF remains to be elucidated. In this study, the crystal structure of LprF has been determined at 1.1 A resolution. The overall structure is similar to that of a homologue, LprG, with a central hydrophobic cavity that binds a triacylated glycolipid. LprF exhibited a central cavity structure similar to that of LprG, but with a smaller cavity that binds two alkyl chains. Consistently, subsequent mass-spectrometric analysis revealed that the bound ligand was a diacylated glycolipid, as found in the structure. Furthermore, an increased ratio of lipoarabinomannan to lipomannan in the mycobacterial cell wall was observed when lprF was introduced into M. smegmatis. These observations suggested that LprF transfers the diacylated glycolipid from the plasma membrane to the cell wall, which might be related to the pathogenesis of the bacteria.
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Crystal structure and functional implications of LprF from Mycobacterium tuberculosis and M. bovis.,Kim JS, Jiao L, Oh JI, Ha NC, Kim YH Acta Crystallogr D Biol Crystallogr. 2014 Oct 1;70(Pt 10):2619-30. doi:, 10.1107/S1399004714016599. Epub 2014 Sep 27. PMID:25286846<ref>PMID:25286846</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ha, N C.]]
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[[Category: Large Structures]]
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[[Category: Jiao, L.]]
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[[Category: Mycobacterium tuberculosis variant bovis AF2122/97]]
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[[Category: Kim, J S.]]
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[[Category: Ha NC]]
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[[Category: Diacylated glycolipid]]
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[[Category: Jiao L]]
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[[Category: Lipid transfer]]
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[[Category: Kim JS]]
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[[Category: Lipid transport]]
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Current revision

Crystal structure of LprF from Mycobacterium bovis

PDB ID 4qa8

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