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2xc3

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==X-RAY STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS CYP125 BOUND TO THE REVERSE TYPE I INHIBITOR==
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<StructureSection load='2xc3' size='340' side='right' caption='[[2xc3]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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==X-ray structure of Mycobacterium tuberculosis cyp125 bound to the reverse type I inhibitor==
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<StructureSection load='2xc3' size='340' side='right'caption='[[2xc3]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xc3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XC3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xc3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XC3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=RT8:NALPHA-[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]-N-PYRIDIN-4-YL-D-TRYPTOPHANAMIDE'>RT8</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2x5w|2x5w]], [[2x5l|2x5l]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=RT8:NALPHA-[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]-N-PYRIDIN-4-YL-D-TRYPTOPHANAMIDE'>RT8</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xc3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xc3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xc3 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xc3 OCA], [https://pdbe.org/2xc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xc3 RCSB], [https://www.ebi.ac.uk/pdbsum/2xc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xc3 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CP125_MYCTU CP125_MYCTU] Catalyzes the C-27 hydroxylation of cholest-4-en-3-one and cholesterol and subsequently oxidizes the alcohol of the former to the cholest-4-en-3-one-27-oic acid via the aldehyde intermediate. Not required to incorporate the cholesterol side-chain carbon atoms into cellular lipids.<ref>PMID:19846551</ref> <ref>PMID:20545858</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2xc3" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Large Structures]]
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[[Category: Kells, P M.]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Montellano, P R.Ortiz De.]]
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[[Category: Kells PM]]
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[[Category: Ouellet, H.]]
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[[Category: Ortiz de Montellano PR]]
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[[Category: Podust, L M.]]
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[[Category: Ouellet H]]
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[[Category: Metal-binding]]
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[[Category: Podust LM]]
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[[Category: Oxidoreductase]]
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Current revision

X-ray structure of Mycobacterium tuberculosis cyp125 bound to the reverse type I inhibitor

PDB ID 2xc3

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