4rls
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4rls is ON HOLD Authors: Eigenbrot, C., Ultsch, M.H. Description: Lactate Dehydrogenase in complex with inhibitor compound 49) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Lactate Dehydrogenase in complex with inhibitor compound 47== | |
| + | <StructureSection load='4rls' size='340' side='right'caption='[[4rls]], [[Resolution|resolution]] 1.91Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4rls]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RLS FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=49C:(1R)-5-[(2-CHLOROPHENYL)SULFANYL]-4-HYDROXY-2,3-DIHYDROSPIRO[INDENE-1,2-PYRAN]-6(3H)-ONE'>49C</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rls OCA], [https://pdbe.org/4rls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rls RCSB], [https://www.ebi.ac.uk/pdbsum/4rls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rls ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[https://omim.org/entry/612933 612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN] | ||
| - | + | ==See Also== | |
| - | + | *[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Eigenbrot C]] | ||
| + | [[Category: Ultsch MH]] | ||
Current revision
Lactate Dehydrogenase in complex with inhibitor compound 47
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